Cargando…

Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1

Human flap endonuclease-1 (hFEN1) catalyzes the divalent metal ion-dependent removal of single-stranded DNA protrusions known as flaps during DNA replication and repair. Substrate selectivity involves passage of the 5′-terminus/flap through the arch and recognition of a single nucleotide 3′-flap by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bennet, Ian A, Finger, L David, Baxter, Nicola J, Ambrose, Benjamin, Hounslow, Andrea M, Thompson, Mark J, Exell, Jack C, Shahari, Nur Nazihah B Md, Craggs, Timothy D, Waltho, Jonathan P, Grasby, Jane A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009646/ https://www.ncbi.nlm.nih.gov/pubmed/29718417 http://dx.doi.org/10.1093/nar/gky293

Ejemplares similares

Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends
por: Patel, Nikesh, et al.
Publicado: (2012)

Human RECQL5β stimulates flap endonuclease 1
por: Speina, Elżbieta, et al.
Publicado: (2010)

Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1
por: Xu, Hong, et al.
Publicado: (2018)

DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction
por: Algasaier, Sana I., et al.
Publicado: (2016)

Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1
por: Xu, Meng, et al.
Publicado: (2013)

Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner
por: Becker, Jordan R, et al.
Publicado: (2018)

Dissecting endonuclease and exonuclease activities in endonuclease V from Thermotoga maritima
por: Mi, Rongjuan, et al.
Publicado: (2011)

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe
por: Nilsen, Line, et al.
Publicado: (2012)

The sliding clamp tethers the endonuclease domain of MutL to DNA
por: Pillon, Monica C., et al.
Publicado: (2015)

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
por: Yosaatmadja, Yuliana, et al.
Publicado: (2021)

Cleavage of a model DNA replication fork by a methyl-specific endonuclease
por: Ishikawa, Ken, et al.
Publicado: (2011)

Abasic site–peptide cross-links are blocking lesions repaired by AP endonucleases
por: Yudkina, Anna V, et al.
Publicado: (2023)

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins
por: Li, Hui, et al.
Publicado: (2009)

Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease
por: van Nierop, Gijsbert P., et al.
Publicado: (2009)

Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites
por: Collier, Christopher, et al.
Publicado: (2012)

Cleavage of a model DNA replication fork by a Type I restriction endonuclease
por: Ishikawa, Ken, et al.
Publicado: (2009)

Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics
por: Hoitsma, Nicole M, et al.
Publicado: (2023)

Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus
por: Kiyonari, Shinichi, et al.
Publicado: (2009)

Phage T4 mobE promotes trans homing of the defunct homing endonuclease I-TevIII
por: Wilson, Gavin W., et al.
Publicado: (2009)

Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA
por: Broxson, Christopher, et al.
Publicado: (2014)

Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage
por: Saugar, Irene, et al.
Publicado: (2013)

Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis
por: Mohapatra, Susovan, et al.
Publicado: (2011)

A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes
por: Fadden, Andrew J., et al.
Publicado: (2013)

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair
por: Beaver, Jill M., et al.
Publicado: (2015)

Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable
por: Jensen, Kristi L., et al.
Publicado: (2016)

Bacterial EndoMS/NucS acts as a clamp-mediated mismatch endonuclease to prevent asymmetric accumulation of replication errors
por: Takemoto, Norihiko, et al.
Publicado: (2018)

The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension
por: Witte, Scott J, et al.
Publicado: (2023)

A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase β
por: Pei, De-Sheng, et al.
Publicado: (2011)

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
por: Al-Minawi, Ali Z., et al.
Publicado: (2009)

Identification of a novel structure-specific endonuclease AziN that contributes to the repair of azinomycin B-mediated DNA interstrand crosslinks
por: Chen, Xiaorong, et al.
Publicado: (2020)

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection
por: Roy, Jennie C L, et al.
Publicado: (2021)

GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one
por: Halabi, Anasheh, et al.
Publicado: (2018)

Real-time single-molecule studies of the motions of DNA polymerase fingers illuminate DNA synthesis mechanisms
por: Evans, Geraint W., et al.
Publicado: (2015)

Observation of unpaired substrate DNA in the flap endonuclease-1 active site
por: David Finger, L., et al.
Publicado: (2013)

When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD
por: Marston, Farhat Y., et al.
Publicado: (2010)

Metal-induced DNA translocation leads to DNA polymerase conformational activation
por: Kirby, Thomas W., et al.
Publicado: (2012)

Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS
por: LeBlanc, Sharonda J, et al.
Publicado: (2018)

Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction
por: Sidhu, Arshdeep, et al.
Publicado: (2020)

M. tuberculosis class II apurinic/ apyrimidinic‐endonuclease/3′‐5′ exonuclease (XthA) engages with NAD(+)-dependent DNA ligase A (LigA) to counter futile cleavage and ligation cycles in base excision repair
por: Khanam, Taran, et al.
Publicado: (2020)

Interconversion between bound and free conformations of LexA orchestrates the bacterial SOS response
por: Butala, Matej, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_j5em2bqaoqjdt646f904utg92g