Cargando…

Mechanistic alternatives for peptide bond formation on the ribosome

The peptidyl transfer reaction on the large ribosomal subunit depends on the protonation state of the amine nucleophile and exhibits a large kinetic solvent isotope effect (KSIE ∼8). In contrast, the related peptidyl-tRNA hydrolysis reaction involved in termination shows a KSIE of ∼4 and a pH-rate p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kazemi, Masoud, Sočan, Jaka, Himo, Fahmi, Åqvist, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009655/ https://www.ncbi.nlm.nih.gov/pubmed/29746669 http://dx.doi.org/10.1093/nar/gky367

Ejemplares similares

Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds
por: Bose, Tanaya, et al.
Publicado: (2022)

Outwitting EF-Tu and the ribosome: translation with d-amino acids
por: Achenbach, John, et al.
Publicado: (2015)

Landscape of the complete RNA chemical modifications in the human 80S ribosome
por: Taoka, Masato, et al.
Publicado: (2018)

Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis
por: Stephens, Dominique C., et al.
Publicado: (2016)

Small synthetic molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshifting
por: Matsumoto, Saki, et al.
Publicado: (2018)

Sulfur-centered hemi-bond radicals as active intermediates in S-DNA phosphorothioate oxidation
por: Jie, Jialong, et al.
Publicado: (2019)

The effect of adenine protonation on RNA phosphodiester backbone bond cleavage elucidated by deaza-nucleobase modifications and mass spectrometry
por: Fuchs, Elisabeth, et al.
Publicado: (2019)

The effects of DNA supercoiling on G-quadruplex formation
por: Sekibo, Doreen A.T., et al.
Publicado: (2017)

Constrained peptides mimic a viral suppressor of RNA silencing
por: Kuepper, Arne, et al.
Publicado: (2021)

Regioselective formation of RNA strands in the absence of magnesium ions
por: Motsch, Sebastian, et al.
Publicado: (2020)

AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes
por: Garabedian, Alyssa, et al.
Publicado: (2022)

Systematic investigation of sequence requirements for DNA i-motif formation
por: Školáková, Petra, et al.
Publicado: (2019)

Pseudorotaxane formation via the slippage process with chemically cyclized oligonucleotides
por: Onizuka, Kazumitsu, et al.
Publicado: (2017)

VEZF1–guanine quadruplex DNA interaction regulates alternative polyadenylation and detyrosinase activity of VASH1
por: Li, Lin, et al.
Publicado: (2020)

Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis
por: Rietmeyer, Lauriane, et al.
Publicado: (2022)

Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation
por: Onizuka, Kazumitsu, et al.
Publicado: (2018)

Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung
por: Dang, Yan, et al.
Publicado: (2021)

Cytosine epigenetic modification modulates the formation of an unprecedented G4 structure in the WNT1 promoter
por: Wang, Zi-Fu, et al.
Publicado: (2020)

Modification of the aminopyridine unit of 2′-deoxyaminopyridinyl-pseudocytidine allowing triplex formation at CG interruptions in homopurine sequences
por: Wang, Lei, et al.
Publicado: (2018)

Incorporating uracil and 5-halouracils into short peptide nucleic acids for enhanced recognition of A–U pairs in dsRNAs
por: Patil, Kiran M, et al.
Publicado: (2018)

Modulation of cyclobutane thymine photodimer formation in T(11)-tracts in rotationally phased nucleosome core particles and DNA minicircles
por: Wang, Kesai, et al.
Publicado: (2017)

Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex
por: Dutta, Debasish, et al.
Publicado: (2018)

The effect of flanking bases on direct and triplet sensitized cyclobutane pyrimidine dimer formation in DNA depends on the dipyrimidine, wavelength and the photosensitizer
por: Lu, Chen, et al.
Publicado: (2021)

Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells
por: Sengupta, Pallabi, et al.
Publicado: (2018)

Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy
por: Shabanpoor, Fazel, et al.
Publicado: (2015)

Human TDP1, APE1 and TREX1 repair 3′-DNA–peptide/protein cross-links arising from abasic sites in vitro
por: Wei, Xiaoying, et al.
Publicado: (2022)

Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5′-3′ exoribonuclease) in the nucleoplasm
por: Sato, Shigeko, et al.
Publicado: (2015)

Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site
por: Melnikov, Sergey V, et al.
Publicado: (2019)

Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA
por: Price, Nathan E., et al.
Publicado: (2015)

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity
por: Prakash, Thazha P., et al.
Publicado: (2015)

Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs
por: Ohkubo, Akihiro, et al.
Publicado: (2015)

Site-specific labeling of RNA by combining genetic alphabet expansion transcription and copper-free click chemistry
por: Someya, Tatsuhiko, et al.
Publicado: (2015)

Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule
por: Shan, Chan, et al.
Publicado: (2015)

Linking two DNA duplexes with a rigid linker for DNA nanotechnology
por: Tashiro, Ryu, et al.
Publicado: (2015)

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties
por: Maiti, Mohitosh, et al.
Publicado: (2015)

The unusual and dynamic character of PX-DNA
por: Niu, Dong, et al.
Publicado: (2015)

Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation
por: Wang, Peng, et al.
Publicado: (2015)

DNA–DNA kissing complexes as a new tool for the assembly of DNA nanostructures
por: Barth, Anna, et al.
Publicado: (2016)

Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells
por: Shopsowitz, Kevin E., et al.
Publicado: (2016)

The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta
por: Choi, Jung-Suk, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rld28akai541qb751ri93nrurk