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The structure of the TsaB/TsaD/TsaE complex reveals an unexpected mechanism for the bacterial t(6)A tRNA-modification

The universal N(6)-threonylcarbamoyladenosine (t(6)A) modification at position A37 of ANN-decoding tRNAs is essential for translational fidelity. In bacteria the TsaC enzyme first synthesizes an l-threonylcarbamoyladenylate (TC-AMP) intermediate. In cooperation with TsaB and TsaE, TsaD then transfer...

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Detalles Bibliográficos
Autores principales: Missoury, Sophia, Plancqueel, Stéphane, Li de la Sierra-Gallay, Ines, Zhang, Wenhua, Liger, Dominique, Durand, Dominique, Dammak, Raoudha, Collinet, Bruno, van Tilbeurgh, Herman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009658/
https://www.ncbi.nlm.nih.gov/pubmed/29741707
http://dx.doi.org/10.1093/nar/gky323

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