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Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing
We studied the genetic diversity of Cryptosporidium hominis infections in slum-dwelling infants from Dhaka over a 2-year period. Cryptosporidium hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole-genome resequencing. Recombination...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009673/ https://www.ncbi.nlm.nih.gov/pubmed/29514308 http://dx.doi.org/10.1093/infdis/jiy121 |
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| author | Gilchrist, Carol A Cotton, James A Burkey, Cecelia Arju, Tuhinur Gilmartin, Allissia Lin, Ye Ahmed, Emtiaz Steiner, Kevin Alam, Masud Ahmed, Shahnawaz Robinson, Guy Zaman, Sultan Uz Kabir, Mamun Sanders, Mandy Chalmers, Rachel M Ahmed, Tahmeed Ma, Jennie Z Haque, Rashidul Faruque, Abu S G Berriman, Matthew Petri, William A |
| author_facet | Gilchrist, Carol A Cotton, James A Burkey, Cecelia Arju, Tuhinur Gilmartin, Allissia Lin, Ye Ahmed, Emtiaz Steiner, Kevin Alam, Masud Ahmed, Shahnawaz Robinson, Guy Zaman, Sultan Uz Kabir, Mamun Sanders, Mandy Chalmers, Rachel M Ahmed, Tahmeed Ma, Jennie Z Haque, Rashidul Faruque, Abu S G Berriman, Matthew Petri, William A |
| author_sort | Gilchrist, Carol A |
| collection | PubMed |
| description | We studied the genetic diversity of Cryptosporidium hominis infections in slum-dwelling infants from Dhaka over a 2-year period. Cryptosporidium hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole-genome resequencing. Recombination in the parasite was evidenced by the decay of linkage disequilibrium in the genome over <300 bp. Regions of the genome with high levels of polymorphism were also identified. Yet to be determined is if genomic diversity is responsible in part for the high rate of reinfection, seasonality, and varied clinical presentations of cryptosporidiosis in this population. |
| format | Online Article Text |
| id | pubmed-6009673 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60096732018-06-25 Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing Gilchrist, Carol A Cotton, James A Burkey, Cecelia Arju, Tuhinur Gilmartin, Allissia Lin, Ye Ahmed, Emtiaz Steiner, Kevin Alam, Masud Ahmed, Shahnawaz Robinson, Guy Zaman, Sultan Uz Kabir, Mamun Sanders, Mandy Chalmers, Rachel M Ahmed, Tahmeed Ma, Jennie Z Haque, Rashidul Faruque, Abu S G Berriman, Matthew Petri, William A J Infect Dis Major Articles and Brief Reports We studied the genetic diversity of Cryptosporidium hominis infections in slum-dwelling infants from Dhaka over a 2-year period. Cryptosporidium hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole-genome resequencing. Recombination in the parasite was evidenced by the decay of linkage disequilibrium in the genome over <300 bp. Regions of the genome with high levels of polymorphism were also identified. Yet to be determined is if genomic diversity is responsible in part for the high rate of reinfection, seasonality, and varied clinical presentations of cryptosporidiosis in this population. Oxford University Press 2018-07-15 2018-03-05 /pmc/articles/PMC6009673/ /pubmed/29514308 http://dx.doi.org/10.1093/infdis/jiy121 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Major Articles and Brief Reports Gilchrist, Carol A Cotton, James A Burkey, Cecelia Arju, Tuhinur Gilmartin, Allissia Lin, Ye Ahmed, Emtiaz Steiner, Kevin Alam, Masud Ahmed, Shahnawaz Robinson, Guy Zaman, Sultan Uz Kabir, Mamun Sanders, Mandy Chalmers, Rachel M Ahmed, Tahmeed Ma, Jennie Z Haque, Rashidul Faruque, Abu S G Berriman, Matthew Petri, William A Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing |
| title | Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing |
| title_full | Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing |
| title_fullStr | Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing |
| title_full_unstemmed | Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing |
| title_short | Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing |
| title_sort | genetic diversity of cryptosporidium hominis in a bangladeshi community as revealed by whole-genome sequencing |
| topic | Major Articles and Brief Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009673/ https://www.ncbi.nlm.nih.gov/pubmed/29514308 http://dx.doi.org/10.1093/infdis/jiy121 |
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