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IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population
BACKGROUND: There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF) in different ethnicities across the globe. AF increases the risk of stroke and heart failure. Despite various researches on IL‐10 response, ther...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009777/ https://www.ncbi.nlm.nih.gov/pubmed/29951144 http://dx.doi.org/10.1002/joa3.12074 |
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author | Yadav, Surabhi Akhtar, Salman Agarwal, Surendra K. Majumdar, Gauranga Vimal, Suman Sharma, Mala |
author_facet | Yadav, Surabhi Akhtar, Salman Agarwal, Surendra K. Majumdar, Gauranga Vimal, Suman Sharma, Mala |
author_sort | Yadav, Surabhi |
collection | PubMed |
description | BACKGROUND: There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF) in different ethnicities across the globe. AF increases the risk of stroke and heart failure. Despite various researches on IL‐10 response, there is limited clinical evidence present, which demonstrate a role of these immunity regulators in AF. Therefore, this study was designed to decipher the role of IL‐10(‐592A/C) polymorphism in the development of postoperative AF (post‐OP AF). METHOD: The study was designed for north Indian patients. The study included 90 patients with AF and 126 controls in sinus rhythm undergoing surgery at Department of Cardiovascular and thoracic surgery, SGPGIMS, Lucknow, India. DNA samples were genotyped for common single nucleotide polymorphism (SNP) in gene IL‐10(‐592A/C). The PCR‐based RFLP technique was used to assess the genotype frequencies. The multivariable logistic regression analysis was performed to study the association of other risk factors with AF. RESULTS: The distribution of IL‐10(‐592A/C) genotypes (CC, AC, and AA) was found to be 48.41%, 47.61%, and 3.98% in controls and 41.11%, 45.55%, and 13.34% in cases, respectively (P = .0385). The frequency of allele A in cases was significantly higher than the control group (36.11% vs 27.77%, P = .0654). Compared with CC, AA genotype had increased risk of AF in both unadjusted and adjusted analyses. CONCLUSIONS: This study suggests that IL‐10(‐592A/C) polymorphism may have significant association with post‐OP AF development in north Indian patients. |
format | Online Article Text |
id | pubmed-6009777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60097772018-06-27 IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population Yadav, Surabhi Akhtar, Salman Agarwal, Surendra K. Majumdar, Gauranga Vimal, Suman Sharma, Mala J Arrhythm Original Articles BACKGROUND: There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF) in different ethnicities across the globe. AF increases the risk of stroke and heart failure. Despite various researches on IL‐10 response, there is limited clinical evidence present, which demonstrate a role of these immunity regulators in AF. Therefore, this study was designed to decipher the role of IL‐10(‐592A/C) polymorphism in the development of postoperative AF (post‐OP AF). METHOD: The study was designed for north Indian patients. The study included 90 patients with AF and 126 controls in sinus rhythm undergoing surgery at Department of Cardiovascular and thoracic surgery, SGPGIMS, Lucknow, India. DNA samples were genotyped for common single nucleotide polymorphism (SNP) in gene IL‐10(‐592A/C). The PCR‐based RFLP technique was used to assess the genotype frequencies. The multivariable logistic regression analysis was performed to study the association of other risk factors with AF. RESULTS: The distribution of IL‐10(‐592A/C) genotypes (CC, AC, and AA) was found to be 48.41%, 47.61%, and 3.98% in controls and 41.11%, 45.55%, and 13.34% in cases, respectively (P = .0385). The frequency of allele A in cases was significantly higher than the control group (36.11% vs 27.77%, P = .0654). Compared with CC, AA genotype had increased risk of AF in both unadjusted and adjusted analyses. CONCLUSIONS: This study suggests that IL‐10(‐592A/C) polymorphism may have significant association with post‐OP AF development in north Indian patients. John Wiley and Sons Inc. 2018-05-22 /pmc/articles/PMC6009777/ /pubmed/29951144 http://dx.doi.org/10.1002/joa3.12074 Text en © 2018 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Yadav, Surabhi Akhtar, Salman Agarwal, Surendra K. Majumdar, Gauranga Vimal, Suman Sharma, Mala IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population |
title |
IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population |
title_full |
IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population |
title_fullStr |
IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population |
title_full_unstemmed |
IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population |
title_short |
IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population |
title_sort | il‐10(‐592a/c) gene variant a predictor of postoperative atrial fibrillation in the north indian population |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009777/ https://www.ncbi.nlm.nih.gov/pubmed/29951144 http://dx.doi.org/10.1002/joa3.12074 |
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