Cargando…

Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity

BACKGROUND & AIMS: Clostridium difficile toxin A (TcdA) and C difficile toxin toxin B (TcdB), the major virulence factors of the bacterium, cause intestinal tissue damage and inflammation. Although the 2 toxins are homologous and share a similar domain structure, TcdA is generally more inflammat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yongrong, Li, Shan, Yang, Zhiyong, Shi, Lianfa, Yu, Hua, Salerno-Goncalves, Rosangela, Saint Fleur, Ashley, Feng, Hanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009800/ https://www.ncbi.nlm.nih.gov/pubmed/29930981 http://dx.doi.org/10.1016/j.jcmgh.2018.01.022

Ejemplares similares

A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity
por: Zhang, Yongrong, et al.
Publicado: (2013)

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins
por: Shen, Aimee, et al.
Publicado: (2011)

A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins
por: Sun, Ying, et al.
Publicado: (2023)

The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota
por: Zhang, Yongrong, et al.
Publicado: (2022)

Utility of Clostridium difficile Toxin B for Inducing Anti-Tumor Immunity
por: Huang, Tuxiong, et al.
Publicado: (2014)

The Enterotoxicity of Clostridium difficile Toxins
por: Sun, Xingmin, et al.
Publicado: (2010)

On and Off: A Dual Role for Cysteine Protease Autoprocessing of C difficile Toxin B on Cytotoxicity vs Proinflammatory Toxin Actions?
por: Chen, Xinhua, et al.
Publicado: (2018)

Structure of the full-length Clostridium difficile toxin B
por: Chen, Peng, et al.
Publicado: (2019)

Novel Cysteine Desulfidase CdsB Involved in Releasing Cysteine Repression of Toxin Synthesis in Clostridium difficile
por: Gu, Huawei, et al.
Publicado: (2018)

Identification of an Essential Region for Translocation of Clostridium difficile Toxin B
por: Chen, Shuyi, et al.
Publicado: (2016)

Identification of Toxemia in Patients with Clostridium difficile Infection
por: Yu, Hua, et al.
Publicado: (2015)

Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism
por: Krautz-Peterson, Greice, et al.
Publicado: (2012)

Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin
por: Jurėnas, Dukas, et al.
Publicado: (2021)

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
por: Yang, Guilin, et al.
Publicado: (2008)

Correction: Chen, S., et al. Identification of an Essential Region for Translocation of Clostridium difficile Toxin B. Toxins 2016, 8, 241
por: Chen, Shuyi, et al.
Publicado: (2016)

Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide
por: Bradshaw, William J., et al.
Publicado: (2015)

Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B
por: Yuan, Pengfei, et al.
Publicado: (2015)

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
por: Genth, Harald, et al.
Publicado: (2016)

Toxin B is essential for virulence of Clostridium difficile
por: Lyras, Dena, et al.
Publicado: (2009)

The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile
por: Bradshaw, William J., et al.
Publicado: (2014)

Binary Toxin and Death after Clostridium difficile Infection
por: Bacci, Sabrina, et al.
Publicado: (2011)

Spore Formation and Toxin Production in Clostridium difficile Biofilms
por: Semenyuk, Ekaterina G., et al.
Publicado: (2014)

The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins
por: Chen, Shuyi, et al.
Publicado: (2015)

The Regulatory Networks That Control Clostridium difficile Toxin Synthesis
por: Martin-Verstraete, Isabelle, et al.
Publicado: (2016)

Computational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to autocleavage
por: Bonadio, Alessandro, et al.
Publicado: (2023)

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin
por: Schnell, Leonie, et al.
Publicado: (2016)

Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode
por: Chen, Shuai, et al.
Publicado: (2010)

Clostridium difficile toxin B induces autophagic cell death in colonocytes
por: Chan, Hung, et al.
Publicado: (2018)

Clostridium difficile Infection Caused by Binary Toxin–Positive Strains
por: Hensgens, Marjolein P.M., et al.
Publicado: (2013)

Genes Encoding Toxin of Clostridium difficile in Children with and without Diarrhea
por: Merino, Victor R. C., et al.
Publicado: (2014)

Toxin Synthesis by Clostridium difficile Is Regulated through Quorum Signaling
por: Darkoh, Charles, et al.
Publicado: (2015)

Increased toxin expression in a Clostridium difficile mfd mutant
por: Willing, Stephanie E., et al.
Publicado: (2015)

Frizzled are colonic epithelial receptors for Clostridium difficile toxin B
por: Tao, Liang, et al.
Publicado: (2016)

Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage
por: Shkilnyj, Paul, et al.
Publicado: (2013)

Proinflammatory Cytokines: Possible Accomplices for the Systemic Effects of Clostridioides difficile Toxin B
por: Fettucciari, Katia, et al.
Publicado: (2021)

Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
por: Kuehne, Sarah A., et al.
Publicado: (2014)

Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
por: Simeon, Rudo, et al.
Publicado: (2019)

Erratum to: Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode
por: Chen, Shuai, et al.
Publicado: (2010)

The Cysteine Protease α-Clostripain is Not Essential for the Pathogenesis of Clostridium perfringens-Mediated Myonecrosis
por: Chakravorty, Anjana, et al.
Publicado: (2011)

Toward a structural understanding of Clostridium difficile toxins A and B
por: Pruitt, Rory N., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cvcgl77dshlcgr0f7rb9v2btra