Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity

Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 c...

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Detalles Bibliográficos
Autores principales: Ruan, Ban-Feng, Ge, Wei-Wei, Cheng, Hui-Jie, Xu, Hua-Jian, Li, Qing-Shan, Liu, Xin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009859/
https://www.ncbi.nlm.nih.gov/pubmed/29072109
http://dx.doi.org/10.1080/14756366.2017.1381090
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author Ruan, Ban-Feng
Ge, Wei-Wei
Cheng, Hui-Jie
Xu, Hua-Jian
Li, Qing-Shan
Liu, Xin-Hua
author_facet Ruan, Ban-Feng
Ge, Wei-Wei
Cheng, Hui-Jie
Xu, Hua-Jian
Li, Qing-Shan
Liu, Xin-Hua
author_sort Ruan, Ban-Feng
collection PubMed
description Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway.
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spelling pubmed-60098592018-07-11 Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity Ruan, Ban-Feng Ge, Wei-Wei Cheng, Hui-Jie Xu, Hua-Jian Li, Qing-Shan Liu, Xin-Hua J Enzyme Inhib Med Chem Short Communication Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway. Taylor & Francis 2017-10-26 /pmc/articles/PMC6009859/ /pubmed/29072109 http://dx.doi.org/10.1080/14756366.2017.1381090 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Ruan, Ban-Feng
Ge, Wei-Wei
Cheng, Hui-Jie
Xu, Hua-Jian
Li, Qing-Shan
Liu, Xin-Hua
Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
title Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
title_full Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
title_fullStr Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
title_full_unstemmed Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
title_short Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
title_sort resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009859/
https://www.ncbi.nlm.nih.gov/pubmed/29072109
http://dx.doi.org/10.1080/14756366.2017.1381090
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