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Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach

Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. CTS bind to the various NKA isoforms that are expressed in different cell types, which gives CTS their narrow therapeutic index. We have synthesised a series of digoxin derivatives (γ-Benzyliden...

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Detalles Bibliográficos
Autores principales:	Pessôa, Marco T. C., Alves, Silmara L. G., Taranto, Alex G., Villar, José A. F. P., Blanco, Gustavo, Barbosa, Leandro A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009882/ https://www.ncbi.nlm.nih.gov/pubmed/29115894 http://dx.doi.org/10.1080/14756366.2017.1380637

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