Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site

A series of 2-amino-5-nitrothiazole derived semicarbazones were designed, synthesised and investigated for MAO and ChE inhibition properties. Most of the compounds showed preferential inhibition towards MAO-B. Compound 4, (1-(1-(4-Bromophenyl)ethylidene)-4-(5-nitrothiazol-2-yl)semicarbazide) emerged...

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Detalles Bibliográficos
Autores principales: Tripathi, Rati K. P., M. Sasi, Vishnu, Gupta, Sukesh K., Krishnamurthy, Sairam, Ayyannan, Senthil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009888/
https://www.ncbi.nlm.nih.gov/pubmed/29098902
http://dx.doi.org/10.1080/14756366.2017.1389920

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