1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Several neurodegenerative disorders including Alzheimer’s disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic strategy against such pathologies. Recently, novel class of CK1-specific inhibitors with N-(ben...

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Detalles Bibliográficos
Autores principales: Benek, Ondrej, Hroch, Lukas, Aitken, Laura, Gunn-Moore, Frank, Vinklarova, Lucie, Kuca, Kamil, Perez, Daniel I., Perez, Concepcion, Martinez, Ana, Fisar, Zdenek, Musilek, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009902/
https://www.ncbi.nlm.nih.gov/pubmed/29536773
http://dx.doi.org/10.1080/14756366.2018.1445736

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