A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability

Context: The nitrobezoxadiazole derivative NBDHEX is a potent inhibitor of glutathione transferase P1-1 (GSTP1-1) endowed with outstanding anticancer activity in different tumor models. Objective: To characterize by in vitro biochemical and in silico studies the NBDHEX analogues named MC2752 and MC2...

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Detalles Bibliográficos
Autores principales: Fulci, Chiara, Rotili, Dante, De Luca, Anastasia, Stella, Lorenzo, Morozzo della Rocca, Blasco, Forgione, Mariantonietta, Di Paolo, Veronica, Mai, Antonello, Falconi, Mattia, Quintieri, Luigi, Caccuri, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009906/
https://www.ncbi.nlm.nih.gov/pubmed/28097896
http://dx.doi.org/10.1080/14756366.2016.1247059

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