Design, synthesis and biological evaluation of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives as novel FGFR1 inhibitors for treatment of non-small cell lung cancer

A series of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives were designed and synthesised as novel fibroblast growth factor receptor-1 (FGFR1) inhibitors. We found that one of the most promising compounds, C9, inhibited five non-small cell lung cancer (NSCLC) cell lines with FGFR1 amplification...

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Detalles Bibliográficos
Autores principales: Xie, Zixin, Cheng, Donghua, Luo, Lu, Shen, Guoliang, Pan, Suwei, Pan, Yaqian, Chen, Bo, Wang, Xuebao, Liu, Zhiguo, Zhang, Yuan, Ye, Faqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009922/
https://www.ncbi.nlm.nih.gov/pubmed/29734851
http://dx.doi.org/10.1080/14756366.2018.1460824

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