Design, synthesis and biological activity of N(4)-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase

Simultaneous inhibition of multiple kinases has been suggested to provide synergistic effects on inhibition of tumour growth and resistance. This study describes the design, synthesis and evaluation of 18 compounds incorporating a pyrrolo[2,3-d]pyrimidine scaffold for dual inhibition of epidermal gr...

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Detalles Bibliográficos
Autores principales: Kurup, Sonali, McAllister, Bradley, Liskova, Pavlina, Mistry, Trusha, Fanizza, Anthony, Stanford, Dan, Slawska, Jolanta, Keller, Ulrich, Hoellein, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009956/
https://www.ncbi.nlm.nih.gov/pubmed/29115879
http://dx.doi.org/10.1080/14756366.2017.1376666

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