Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the nanomolar concentration range. The best performing compound was preliminarily eva...

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Detalles Bibliográficos
Autores principales: Meleddu, Rita, Distinto, Simona, Cirilli, Roberto, Alcaro, Stefano, Yanez, Matilde, Sanna, Maria Luisa, Corona, Angela, Melis, Claudia, Bianco, Giulia, Matyus, Peter, Cottiglia, Filippo, Maccioni, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009968/
https://www.ncbi.nlm.nih.gov/pubmed/28097874
http://dx.doi.org/10.1080/14756366.2016.1247061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009968/
https://www.ncbi.nlm.nih.gov/pubmed/28097874
http://dx.doi.org/10.1080/14756366.2016.1247061

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