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Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition

After hydrofluorination of ynesulphonamides in superacid or in the presence of hydrofluoric acid/base reagents, a series of α-fluoroenamides has been synthesised and tested for the inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms. This study reveals a new, highly selective family of cancer...

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Detalles Bibliográficos
Autores principales:	Métayer, Benoit, Angeli, Andrea, Mingot, Agnès, Jouvin, Kévin, Evano, Gwilherm, Supuran, Claudiu T., Thibaudeau, Sébastien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009971/ https://www.ncbi.nlm.nih.gov/pubmed/29706097 http://dx.doi.org/10.1080/14756366.2018.1461097

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