Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor

BACKGROUND: Human adipose-derived mesenchymal stem cells (hADSCs) are promising cells that may promote hepatocyte differentiation (Hep-Dif) and improve liver function, but the involvement of Cdc42, a key small RhoGTPase which plays a crucial role in aging, is still not well established. We hypothesi...

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Detalles Bibliográficos
Autores principales: Chaker, Diana, Mouawad, Charbel, Azar, Albert, Quilliot, Didier, Achkar, Ibrahim, Fajloun, Ziad, Makdissy, Nehman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009972/
https://www.ncbi.nlm.nih.gov/pubmed/29921325
http://dx.doi.org/10.1186/s13287-018-0910-5

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