Cargando…

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase

A series of 3-3-{2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihydro-1H-indol-2-one derivatives has been designed and synthesized to study their activity on both HIV-1 (Human Immunodeficiency Virus type 1) RT (Reverse Transcriptase) associated functions. These der...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meleddu, Rita, Distinto, Simona, Corona, Angela, Tramontano, Enzo, Bianco, Giulia, Melis, Claudia, Cottiglia, Filippo, Maccioni, Elias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010014/ https://www.ncbi.nlm.nih.gov/pubmed/27766892 http://dx.doi.org/10.1080/14756366.2016.1238366

Ejemplares similares

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6
por: Corona, Angela, et al.
Publicado: (2016)

Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function
por: Fois, Benedetta, et al.
Publicado: (2021)

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
por: Melis, Claudia, et al.
Publicado: (2016)

Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor
por: Corona, Angela, et al.
Publicado: (2013)

5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action
por: Corona, Angela, et al.
Publicado: (2023)

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B
por: Meleddu, Rita, et al.
Publicado: (2017)

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions
por: Meleddu, Rita, et al.
Publicado: (2021)

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms
por: Bianco, Giulia, et al.
Publicado: (2017)

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases
por: Distinto, Simona, et al.
Publicado: (2019)

Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation
por: Fois, Benedetta, et al.
Publicado: (2020)

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
por: Meleddu, Rita, et al.
Publicado: (2021)

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors
por: Schneider, Anna, et al.
Publicado: (2016)

HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions
por: Esposito, Francesca, et al.
Publicado: (2012)

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
por: Massari, Serena, et al.
Publicado: (2018)

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain
por: Carcelli, Mauro, et al.
Publicado: (2017)

Impact of human immunodeficiency virus type 1 ribonuclease H inhibitors on the polymerase and RNase H function of foamy virus reverse transcriptase
por: Corona, Angela, et al.
Publicado: (2013)

In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds
por: Sanna, Cinzia, et al.
Publicado: (2021)

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
por: Desantis, Jenny, et al.
Publicado: (2020)

Bypassing the proline/thiazoline requirement of the macrocyclase PatG
por: Oueis, E., et al.
Publicado: (2017)

New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation
por: Turan-Zitouni, Gülhan, et al.
Publicado: (2018)

Effects of docosanyl ferulate, a constituent of Withania somnifera, on ethanol- and morphine-elicited conditioned place preference and ERK phosphorylation in the accumbens shell of CD1 mice
por: Maccioni, Riccardo, et al.
Publicado: (2022)

Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H
por: Tocco, Graziella, et al.
Publicado: (2020)

Comparison of Odorants in Beef and Chicken Broth—Focus on Thiazoles and Thiazolines
por: Yeo, Huiqi, et al.
Publicado: (2022)

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase
por: Messore, Antonella, et al.
Publicado: (2021)

Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability
por: Usach, Iris, et al.
Publicado: (2013)

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities
por: Pala, Nicolino, et al.
Publicado: (2016)

Grassypeptolides A−C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides
por: Kwan, Jason C., et al.
Publicado: (2010)

Asymmetric Synthesis of 2,4,5-Trisubstituted Δ(2)-Thiazolines
por: Bengtsson, Christoffer, et al.
Publicado: (2013)

Modular synthesis of thiazoline and thiazole derivatives by using a cascade protocol
por: Alsharif, Zakeyah A., et al.
Publicado: (2017)

A reverse transcriptase ribozyme
por: Samanta, Biswajit, et al.
Publicado: (2017)

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity
por: Bonvicini, Francesca, et al.
Publicado: (2022)

Reverse transcriptase activity in psoriatic lesions: effects of reverse transcriptase inhibitors on keratinocyte proliferation and differentiation
por: Molès, Jean-Pierre, et al.
Publicado: (2009)

The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats
por: Huda, Armela, et al.
Publicado: (2023)

N-Benzylisatin
por: Schutte, M., et al.
Publicado: (2012)

1-Phenylisatin
por: Shukla, Deepak, et al.
Publicado: (2011)

Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis
por: Liu, Minglong, et al.
Publicado: (2023)

Synthesis and Preliminary Antimicrobial Analysis of Isatin–Ferrocene and Isatin–Ferrocenyl Chalcone Conjugates
por: Singh, Amandeep, et al.
Publicado: (2018)

Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations
por: Rocca, Roberta, et al.
Publicado: (2014)

Low rates of nucleoside reverse transcriptase inhibitor and nonnucleoside reverse transcriptase inhibitor drug resistance in Botswana
por: Moyo, Sikhulile, et al.
Publicado: (2019)

Telomerase reverse transcriptase and neurodegenerative diseases
por: Yu, Xin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d63c5vvkua4oftraon9i8nuvnh