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The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
This study aimed to determine antiradical (DPPH(•) and (•)OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified us...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010034/ https://www.ncbi.nlm.nih.gov/pubmed/28097907 http://dx.doi.org/10.1080/14756366.2016.1252759 |
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author | Janjušević, Ljiljana Karaman, Maja Šibul, Filip Tommonaro, Giuseppina Iodice, Carmine Jakovljević, Dragica Pejin, Boris |
author_facet | Janjušević, Ljiljana Karaman, Maja Šibul, Filip Tommonaro, Giuseppina Iodice, Carmine Jakovljević, Dragica Pejin, Boris |
author_sort | Janjušević, Ljiljana |
collection | PubMed |
description | This study aimed to determine antiradical (DPPH(•) and (•)OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (•)OH (3.21 μg/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 μg/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer’s disease. |
format | Online Article Text |
id | pubmed-6010034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-60100342018-07-11 The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents Janjušević, Ljiljana Karaman, Maja Šibul, Filip Tommonaro, Giuseppina Iodice, Carmine Jakovljević, Dragica Pejin, Boris J Enzyme Inhib Med Chem Research Article This study aimed to determine antiradical (DPPH(•) and (•)OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (•)OH (3.21 μg/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 μg/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer’s disease. Taylor & Francis 2017-01-18 /pmc/articles/PMC6010034/ /pubmed/28097907 http://dx.doi.org/10.1080/14756366.2016.1252759 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/Licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Janjušević, Ljiljana Karaman, Maja Šibul, Filip Tommonaro, Giuseppina Iodice, Carmine Jakovljević, Dragica Pejin, Boris The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents |
title | The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents |
title_full | The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents |
title_fullStr | The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents |
title_full_unstemmed | The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents |
title_short | The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents |
title_sort | lignicolous fungus trametes versicolor (l.) lloyd (1920): a promising natural source of antiradical and ache inhibitory agents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010034/ https://www.ncbi.nlm.nih.gov/pubmed/28097907 http://dx.doi.org/10.1080/14756366.2016.1252759 |
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