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The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents

This study aimed to determine antiradical (DPPH(•) and (•)OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified us...

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Autores principales: Janjušević, Ljiljana, Karaman, Maja, Šibul, Filip, Tommonaro, Giuseppina, Iodice, Carmine, Jakovljević, Dragica, Pejin, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010034/
https://www.ncbi.nlm.nih.gov/pubmed/28097907
http://dx.doi.org/10.1080/14756366.2016.1252759
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author Janjušević, Ljiljana
Karaman, Maja
Šibul, Filip
Tommonaro, Giuseppina
Iodice, Carmine
Jakovljević, Dragica
Pejin, Boris
author_facet Janjušević, Ljiljana
Karaman, Maja
Šibul, Filip
Tommonaro, Giuseppina
Iodice, Carmine
Jakovljević, Dragica
Pejin, Boris
author_sort Janjušević, Ljiljana
collection PubMed
description This study aimed to determine antiradical (DPPH(•) and (•)OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (•)OH (3.21 μg/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 μg/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer’s disease.
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spelling pubmed-60100342018-07-11 The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents Janjušević, Ljiljana Karaman, Maja Šibul, Filip Tommonaro, Giuseppina Iodice, Carmine Jakovljević, Dragica Pejin, Boris J Enzyme Inhib Med Chem Research Article This study aimed to determine antiradical (DPPH(•) and (•)OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (•)OH (3.21 μg/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 μg/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer’s disease. Taylor & Francis 2017-01-18 /pmc/articles/PMC6010034/ /pubmed/28097907 http://dx.doi.org/10.1080/14756366.2016.1252759 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/Licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Janjušević, Ljiljana
Karaman, Maja
Šibul, Filip
Tommonaro, Giuseppina
Iodice, Carmine
Jakovljević, Dragica
Pejin, Boris
The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
title The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
title_full The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
title_fullStr The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
title_full_unstemmed The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
title_short The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
title_sort lignicolous fungus trametes versicolor (l.) lloyd (1920): a promising natural source of antiradical and ache inhibitory agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010034/
https://www.ncbi.nlm.nih.gov/pubmed/28097907
http://dx.doi.org/10.1080/14756366.2016.1252759
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