Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives

A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HSD1 inhibition at 5 µM and, furthermore, three of them...

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Detalles Bibliográficos
Autores principales: Niinivehmas, Sanna, Postila, Pekka A., Rauhamäki, Sanna, Manivannan, Elangovan, Kortet, Sami, Ahinko, Mira, Huuskonen, Pasi, Nyberg, Niina, Koskimies, Pasi, Lätti, Sakari, Multamäki, Elina, Juvonen, Risto O., Raunio, Hannu, Pasanen, Markku, Huuskonen, Juhani, Pentikäinen, Olli T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010071/
https://www.ncbi.nlm.nih.gov/pubmed/29620427
http://dx.doi.org/10.1080/14756366.2018.1452919

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