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Synthesis and preliminary structure-activity relationship study of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones as potential checkpoint kinase 1 (Chk1) inhibitors

The serine-threonine checkpoint kinase 1 (Chk1) plays a critical role in the cell cycle arrest in response to DNA damage. In the last decade, Chk1 inhibitors have emerged as a novel therapeutic strategy to potentiate the anti-tumour efficacy of cytotoxic chemotherapeutic agents. In the search for ne...

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Detalles Bibliográficos
Autores principales:	Malvacio, Ivana, Cuzzolin, Alberto, Sturlese, Mattia, Vera, D. Mariano A., Moyano, E. Laura, Moro, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010083/ https://www.ncbi.nlm.nih.gov/pubmed/29210298 http://dx.doi.org/10.1080/14756366.2017.1404592

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