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Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

On account of their significance as apoptosis inducing agents, merging indole and 3-hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents. Consequently, 27 hybrids (6a–r, 9a–f and 11a–c) were synthesised and evaluated for their cytotoxicity against MCF-7, HepG-2 and H...

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Detalles Bibliográficos
Autores principales:	Eldehna, Wagdy M., Abo-Ashour, Mahmoud F., Ibrahim, Hany S., Al-Ansary, Ghada H., Ghabbour, Hazem A., Elaasser, Mahmoud M., Ahmed, Hanaa Y. A., Safwat, Nesreen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010103/ https://www.ncbi.nlm.nih.gov/pubmed/29560733 http://dx.doi.org/10.1080/14756366.2017.1421181

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