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Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations
Rab5 is a small GTPase and a key regulator in early endosomal trafficking. Rab5 and its effectors are involved in a large number of infectious diseases and certain types of cancer. We performed µs atomistic molecular dynamics simulations of inactive and active full-length Rab5 anchored to a complex...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010109/ https://www.ncbi.nlm.nih.gov/pubmed/28090783 http://dx.doi.org/10.1080/14756366.2016.1260564 |