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Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition

Small molecule inhibitors have a powerful blocking action on viral polymerases. The bioavailability of the inhibitor, nevertheless, often raise a significant selectivity constraint and may substantially limit the efficacy of therapy. Phosphonoacetic acid has long been known to possess a restricted p...

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Detalles Bibliográficos
Autores principales:	Mikalkėnas, Algirdas, Ravoitytė, Bazilė, Tauraitė, Daiva, Servienė, Elena, Meškys, Rolandas, Serva, Saulius
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010136/ https://www.ncbi.nlm.nih.gov/pubmed/29372656 http://dx.doi.org/10.1080/14756366.2017.1417275

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