Cargando…

Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and leptin in obese Wistar rats. By HPLC, and after ampl...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Medeiros, Amanda Fernandes, Costa, Izael de Sousa, de Carvalho, Fabiana Maria Coimbra, Kiyota, Sumika, de Souza, Beatriz Blenda Pinheiro, Sifuentes, Daniel Nogoceke, Serquiz, Raphael Paschoal, Maciel, Bruna Leal Lima, Uchôa, Adriana Ferreira, dos Santos, Elizeu Antunes, Morais, Ana Heloneida de Araújo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010142/ https://www.ncbi.nlm.nih.gov/pubmed/29322840 http://dx.doi.org/10.1080/14756366.2017.1419220

Ejemplares similares

Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L
por: de Medeiros, Amanda Fernandes, et al.
Publicado: (2021)

An Insulin Receptor-Binding Multifunctional Protein from Tamarindus indica L. Presents a Hypoglycemic Effect in a Diet-Induced Type 2 Diabetes—Preclinical Study
por: Costa, Izael, et al.
Publicado: (2022)

Trypsin inhibitor from tamarindus indica L. seeds reduces weight gain and food consumption and increases plasmatic cholecystokinin levels
por: do Nascimento Campos Ribeiro, Joycellane Alline, et al.
Publicado: (2015)

Characterization and Pharmacological Properties of a Novel Multifunctional Kunitz Inhibitor from Erythrina velutina Seeds
por: Machado, Richele J. A., et al.
Publicado: (2013)

Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction
por: Carvalho, Fabiana M. C., et al.
Publicado: (2019)

Tamarind (Tamarindus indica L.) Seed a Candidate Protein Source with Potential for Combating SARS-CoV-2 Infection in Obesity
por: Morais, Ana H. de A., et al.
Publicado: (2021)

A Trypsin Inhibitor from Tamarind Reduces Food Intake and Improves Inflammatory Status in Rats with Metabolic Syndrome Regardless of Weight Loss
por: Carvalho, Fabiana M. C., et al.
Publicado: (2016)

Tamarindus indica: Extent of explored potential
por: Bhadoriya, Santosh Singh, et al.
Publicado: (2011)

Assessment of Tamarindus indica Extracts for Antibacterial Activity
por: Nwodo, Uchechukwu U., et al.
Publicado: (2011)

Spasmolytic Activity of Fruits of Tamarindus indica L
por: Ali, N, et al.
Publicado: (2010)

A Lactose-Binding Lectin from the Marine Sponge Cinachyrella Apion (Cal) Induces Cell Death in Human Cervical Adenocarcinoma Cells
por: Rabelo, Luciana, et al.
Publicado: (2012)

Pharmacognostical and physicochemical analysis of Tamarindus indica Linn. stem
por: Kodlady, Naveena, et al.
Publicado: (2012)

Acute Toxicity and Hepatotoxicokinetic Studies of Tamarindus indica Extract
por: Nwodo, Uchechukwu U., et al.
Publicado: (2011)

Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: Systematic review protocol
por: de Medeiros, Amanda Fernandes, et al.
Publicado: (2019)

Antimicrobial activity of extracts from Tamarindus indica L. leaves
por: Escalona-Arranz, Julio César, et al.
Publicado: (2010)

Tamarindus indica Extract as a Promising Antimicrobial and Antivirulence Therapy
por: Ghaly, Mohamed F., et al.
Publicado: (2023)

Nanoparticles Loaded with a Carotenoid-Rich Extract from Cantaloupe Melon Improved Hepatic Retinol Levels in a Diet-Induced Obesity Preclinical Model
por: de Carvalho Gomes, Camila, et al.
Publicado: (2023)

Determination of Anthelmintic Activity of the Leaf and Bark Extract of Tamarindus Indica Linn
por: Das, S. S., et al.
Publicado: (2011)

Tamarindus indica seeds improve carbohydrate and lipid metabolism: An in vivo study
por: Uchenna, Uzukwu Emmanuel, et al.
Publicado: (2018)

Effects of Fractionation and Combinatorial Evaluation of Tamarindus indica Fractions for Antibacterial Activity
por: Nwodo, Uchechukwu U., et al.
Publicado: (2011)

Aqueous extract of Tamarindus indica fruit pulp exhibits antihyperglycaemic activity
por: Krishna, Rajesh Nivesh, et al.
Publicado: (2020)

Insulin-Like Proteins in Plant Sources: A Systematic Review
por: Costa, Izael S, et al.
Publicado: (2020)

Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models
por: Kalra, Pankaj, et al.
Publicado: (2011)

Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves
por: Bhadoriya, Santosh Singh, et al.
Publicado: (2012)

Physicochemical composition of Tamarindus indica L. (Tamarind) in the agro‐ecological zones of Uganda
por: Okello, Jaspher, et al.
Publicado: (2018)

Effect of Tamarindus indica L. and Manihot esculenta Extracts on Antibiotic-resistant Bacteria
por: Lima, Zenon Machado, et al.
Publicado: (2017)

Tamarindus indica Fruit: Pharmacognostical Standardization, Detection of Contaminant, and In Vitro Antioxidant Activity
por: Amir, Mohd, et al.
Publicado: (2019)

Tamarindus indica Fruit: Pharmacognostical Standardization, Detection of Contaminant, and In Vitro Antioxidant Activity
Publicado: (2021)

Bioactive compounds, antibacterial and antioxidant activities of methanol extract of Tamarindus indica Linn.
por: Fagbemi, Kehinde Oluwakemi, et al.
Publicado: (2022)

Botanical aspects, phytochemicals, and toxicity of Tamarindus indica leaf and a systematic review of antioxidant capacities of T. indica leaf extracts
por: Sookying, Sontaya, et al.
Publicado: (2022)

Antioxidant and Hepatoprotective Activity of a New Tablets Formulation from Tamarindus indica L.
por: Rodriguez Amado, Jesús Rafael, et al.
Publicado: (2016)

Knowledge, attitudes and practices in tamarind (Tamarindus indica L) use and conservation in Eastern Uganda
por: Ebifa-Othieno, Esther, et al.
Publicado: (2017)

Anti-inflammatory and analgesic potential of Tamarindus indica Linn. (Fabaceae): a narrative review
por: Komakech, Richard, et al.
Publicado: (2019)

Composition and Rheological Properties of Polysaccharide Extracted from Tamarind (Tamarindus indica L.) Seed
por: Shao, Huimin, et al.
Publicado: (2019)

Use of seed gums from Tamarindus indica and Cassia fistula as controlled-release agents
por: Huanbutta, Kampanart, et al.
Publicado: (2018)

The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches
por: Elmaidomy, Abeer H., et al.
Publicado: (2022)

Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups
por: Yusuf, Helen Ruth, et al.
Publicado: (2023)

Prospection of Fungal Lignocellulolytic Enzymes Produced from Jatoba (Hymenaea courbaril) and Tamarind (Tamarindus indica) Seeds: Scaling for Bioreactor and Saccharification Profile of Sugarcane Bagasse
por: Contato, Alex Graça, et al.
Publicado: (2021)

Effect of Tamarindus indica leaf powder on plasma concentrations of copper, zinc, and iron in fluorotic cows
por: Samal, Pinaki, et al.
Publicado: (2016)

Fabrication of Tamarindus indica seeds extract loaded-cream for photo-aged skin: Visioscan(®) studies
por: Waqas, Muhammad Khurram, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qartirlpaannnb84o2u45fbknc