A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies

Nonsense mutations are present in 10% of patients with CF, produce a premature termination codon in CFTR mRNA causing early termination of translation, and lead to lack of CFTR function. There are no currently available animal models which contain a nonsense mutation in the endogenous Cftr locus tha...

Descripción completa

Detalles Bibliográficos
Autores principales: McHugh, Daniel R., Steele, Miarasa S., Valerio, Dana M., Miron, Alexander, Mann, Rachel J., LePage, David F., Conlon, Ronald A., Cotton, Calvin U., Drumm, Mitchell L., Hodges, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010256/
https://www.ncbi.nlm.nih.gov/pubmed/29924856
http://dx.doi.org/10.1371/journal.pone.0199573

Ejemplares similares

Ejemplares similares