Escherichia coli β-clamp slows down DNA polymerase I dependent nick translation while accelerating ligation

The nick translation property of DNA polymerase I (Pol I) ensures the maturation of Okazaki fragments by removing primer RNAs and facilitating ligation. However, prolonged nick translation traversing downstream DNA is an energy wasting futile process, as Pol I simultaneously polymerizes and depolyme...

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Detalles Bibliográficos
Autores principales: Bhardwaj, Amit, Ghose, Debarghya, Thakur, Krishan Gopal, Dutta, Dipak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010275/
https://www.ncbi.nlm.nih.gov/pubmed/29924849
http://dx.doi.org/10.1371/journal.pone.0199559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010275/
https://www.ncbi.nlm.nih.gov/pubmed/29924849
http://dx.doi.org/10.1371/journal.pone.0199559

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