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Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents

Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with...

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Autores principales: Paes, L.A., Torre, O.H. Della, Henriques, T.B., de Mello, M.P., Celeri, E.H.R.V., Dalgalarrondo, P., Guerra, G., dos Santos, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010321/
https://www.ncbi.nlm.nih.gov/pubmed/29924134
http://dx.doi.org/10.1590/1414-431X20187252
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author Paes, L.A.
Torre, O.H. Della
Henriques, T.B.
de Mello, M.P.
Celeri, E.H.R.V.
Dalgalarrondo, P.
Guerra, G.
dos Santos, A.
author_facet Paes, L.A.
Torre, O.H. Della
Henriques, T.B.
de Mello, M.P.
Celeri, E.H.R.V.
Dalgalarrondo, P.
Guerra, G.
dos Santos, A.
author_sort Paes, L.A.
collection PubMed
description Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with several neurological and mental disorders, including abnormalities in cognitive and emotional processes. The aim of this study was to evaluate the association between the rs6318 SNP of the HTR2C gene and behavioral characteristics exhibited by children and adolescents based on the Child Behavior Checklist (CBCL/6-18) inventory. Eighty-five psychiatric outpatients between 8 and 18 years of age underwent genotyping of the rs6318 SNP. The CBCL/6-18 scale was administered to their caregivers. The chi-squared test was used to assess differences in the frequency of C and G alleles of the rs6318 SNP relative to the grouped CBCL/6-18 scores; significance level was 5%. The presence of the G allele of rs6318 was found to be associated with characteristics of aggressive behavior and social problems, and aggressive behavior was found to be associated with heterozygosis in females. These findings contribute to the identification of mental and behavioral phenotypes associated with gene expression.
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spelling pubmed-60103212018-07-13 Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents Paes, L.A. Torre, O.H. Della Henriques, T.B. de Mello, M.P. Celeri, E.H.R.V. Dalgalarrondo, P. Guerra, G. dos Santos, A. Braz J Med Biol Res Research Article Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with several neurological and mental disorders, including abnormalities in cognitive and emotional processes. The aim of this study was to evaluate the association between the rs6318 SNP of the HTR2C gene and behavioral characteristics exhibited by children and adolescents based on the Child Behavior Checklist (CBCL/6-18) inventory. Eighty-five psychiatric outpatients between 8 and 18 years of age underwent genotyping of the rs6318 SNP. The CBCL/6-18 scale was administered to their caregivers. The chi-squared test was used to assess differences in the frequency of C and G alleles of the rs6318 SNP relative to the grouped CBCL/6-18 scores; significance level was 5%. The presence of the G allele of rs6318 was found to be associated with characteristics of aggressive behavior and social problems, and aggressive behavior was found to be associated with heterozygosis in females. These findings contribute to the identification of mental and behavioral phenotypes associated with gene expression. Associação Brasileira de Divulgação Científica 2018-06-14 /pmc/articles/PMC6010321/ /pubmed/29924134 http://dx.doi.org/10.1590/1414-431X20187252 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Paes, L.A.
Torre, O.H. Della
Henriques, T.B.
de Mello, M.P.
Celeri, E.H.R.V.
Dalgalarrondo, P.
Guerra, G.
dos Santos, A.
Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents
title Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents
title_full Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents
title_fullStr Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents
title_full_unstemmed Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents
title_short Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents
title_sort association between serotonin 2c receptor gene (htr2c) polymorphisms and psychopathological symptoms in children and adolescents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010321/
https://www.ncbi.nlm.nih.gov/pubmed/29924134
http://dx.doi.org/10.1590/1414-431X20187252
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