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SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity
C. elegans SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their d...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010342/ https://www.ncbi.nlm.nih.gov/pubmed/29714684 http://dx.doi.org/10.7554/eLife.34970 |
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author | Wang, Wenke Chaturbedi, Amaresh Wang, Minghui An, Serim Santhi Velayudhan, Satheeja Lee, Siu Sylvia |
author_facet | Wang, Wenke Chaturbedi, Amaresh Wang, Minghui An, Serim Santhi Velayudhan, Satheeja Lee, Siu Sylvia |
author_sort | Wang, Wenke |
collection | PubMed |
description | C. elegans SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their different biological roles. SET-9 and SET-26 bind to H3K4me3 with adjacent acetylation marks in vitro and in vivo. In the soma, SET-26 acts through DAF-16 to modulate longevity. In the germline, SET-9 and SET-26 restrict H3K4me3 domains around SET-9 and SET-26 binding sites, and regulate the expression of specific target genes, with critical consequence on germline development. SET-9 and SET-26 are highly conserved and our findings provide new insights into the functions of these H3K4me3 readers in germline development and longevity. |
format | Online Article Text |
id | pubmed-6010342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60103422018-06-21 SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity Wang, Wenke Chaturbedi, Amaresh Wang, Minghui An, Serim Santhi Velayudhan, Satheeja Lee, Siu Sylvia eLife Chromosomes and Gene Expression C. elegans SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their different biological roles. SET-9 and SET-26 bind to H3K4me3 with adjacent acetylation marks in vitro and in vivo. In the soma, SET-26 acts through DAF-16 to modulate longevity. In the germline, SET-9 and SET-26 restrict H3K4me3 domains around SET-9 and SET-26 binding sites, and regulate the expression of specific target genes, with critical consequence on germline development. SET-9 and SET-26 are highly conserved and our findings provide new insights into the functions of these H3K4me3 readers in germline development and longevity. eLife Sciences Publications, Ltd 2018-05-01 /pmc/articles/PMC6010342/ /pubmed/29714684 http://dx.doi.org/10.7554/eLife.34970 Text en © 2018, Wang et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Chromosomes and Gene Expression Wang, Wenke Chaturbedi, Amaresh Wang, Minghui An, Serim Santhi Velayudhan, Satheeja Lee, Siu Sylvia SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity |
title | SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity |
title_full | SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity |
title_fullStr | SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity |
title_full_unstemmed | SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity |
title_short | SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity |
title_sort | set-9 and set-26 are h3k4me3 readers and play critical roles in germline development and longevity |
topic | Chromosomes and Gene Expression |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010342/ https://www.ncbi.nlm.nih.gov/pubmed/29714684 http://dx.doi.org/10.7554/eLife.34970 |
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