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SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

C. elegans SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their d...

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Autores principales: Wang, Wenke, Chaturbedi, Amaresh, Wang, Minghui, An, Serim, Santhi Velayudhan, Satheeja, Lee, Siu Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010342/
https://www.ncbi.nlm.nih.gov/pubmed/29714684
http://dx.doi.org/10.7554/eLife.34970
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author Wang, Wenke
Chaturbedi, Amaresh
Wang, Minghui
An, Serim
Santhi Velayudhan, Satheeja
Lee, Siu Sylvia
author_facet Wang, Wenke
Chaturbedi, Amaresh
Wang, Minghui
An, Serim
Santhi Velayudhan, Satheeja
Lee, Siu Sylvia
author_sort Wang, Wenke
collection PubMed
description C. elegans SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their different biological roles. SET-9 and SET-26 bind to H3K4me3 with adjacent acetylation marks in vitro and in vivo. In the soma, SET-26 acts through DAF-16 to modulate longevity. In the germline, SET-9 and SET-26 restrict H3K4me3 domains around SET-9 and SET-26 binding sites, and regulate the expression of specific target genes, with critical consequence on germline development. SET-9 and SET-26 are highly conserved and our findings provide new insights into the functions of these H3K4me3 readers in germline development and longevity.
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spelling pubmed-60103422018-06-21 SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity Wang, Wenke Chaturbedi, Amaresh Wang, Minghui An, Serim Santhi Velayudhan, Satheeja Lee, Siu Sylvia eLife Chromosomes and Gene Expression C. elegans SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their different biological roles. SET-9 and SET-26 bind to H3K4me3 with adjacent acetylation marks in vitro and in vivo. In the soma, SET-26 acts through DAF-16 to modulate longevity. In the germline, SET-9 and SET-26 restrict H3K4me3 domains around SET-9 and SET-26 binding sites, and regulate the expression of specific target genes, with critical consequence on germline development. SET-9 and SET-26 are highly conserved and our findings provide new insights into the functions of these H3K4me3 readers in germline development and longevity. eLife Sciences Publications, Ltd 2018-05-01 /pmc/articles/PMC6010342/ /pubmed/29714684 http://dx.doi.org/10.7554/eLife.34970 Text en © 2018, Wang et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Chromosomes and Gene Expression
Wang, Wenke
Chaturbedi, Amaresh
Wang, Minghui
An, Serim
Santhi Velayudhan, Satheeja
Lee, Siu Sylvia
SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity
title SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity
title_full SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity
title_fullStr SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity
title_full_unstemmed SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity
title_short SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity
title_sort set-9 and set-26 are h3k4me3 readers and play critical roles in germline development and longevity
topic Chromosomes and Gene Expression
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010342/
https://www.ncbi.nlm.nih.gov/pubmed/29714684
http://dx.doi.org/10.7554/eLife.34970
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