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Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition
People are better able to empathize with others when they are given information concerning the context driving that person’s experiences. This suggests that people draw on prior memories when empathizing, but the mechanisms underlying this connection remain largely unexplored. The present study inve...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010422/ https://www.ncbi.nlm.nih.gov/pubmed/29925874 http://dx.doi.org/10.1038/s41598-018-24557-y |
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author | Pehrs, Corinna Zaki, Jamil Taruffi, Liila Kuchinke, Lars Koelsch, Stefan |
author_facet | Pehrs, Corinna Zaki, Jamil Taruffi, Liila Kuchinke, Lars Koelsch, Stefan |
author_sort | Pehrs, Corinna |
collection | PubMed |
description | People are better able to empathize with others when they are given information concerning the context driving that person’s experiences. This suggests that people draw on prior memories when empathizing, but the mechanisms underlying this connection remain largely unexplored. The present study investigates how variations in episodic information shape the emotional response towards a movie character. Episodic information is either absent or provided by a written context preceding empathic film clips. It was shown that sad context information increases empathic concern for a movie character. This was tracked by neural activity in the temporal pole (TP) and anterior hippocampus (aHP). Dynamic causal modeling with Bayesian Model Selection has shown that context changes the effective connectivity from left aHP to the right TP. The same crossed-hemispheric coupling was found during rest, when people are left to their own thoughts. We conclude that (i) that the integration of episodic memory also supports the specific case of integrating context into empathic judgments, (ii) the right TP supports emotion processing by integrating episodic memory into empathic inferences, and (iii) lateral integration is a key process for episodic simulation during rest and during task. We propose that a disruption of the mechanism may underlie empathy deficits in clinical conditions, such as autism spectrum disorder. |
format | Online Article Text |
id | pubmed-6010422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60104222018-07-06 Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition Pehrs, Corinna Zaki, Jamil Taruffi, Liila Kuchinke, Lars Koelsch, Stefan Sci Rep Article People are better able to empathize with others when they are given information concerning the context driving that person’s experiences. This suggests that people draw on prior memories when empathizing, but the mechanisms underlying this connection remain largely unexplored. The present study investigates how variations in episodic information shape the emotional response towards a movie character. Episodic information is either absent or provided by a written context preceding empathic film clips. It was shown that sad context information increases empathic concern for a movie character. This was tracked by neural activity in the temporal pole (TP) and anterior hippocampus (aHP). Dynamic causal modeling with Bayesian Model Selection has shown that context changes the effective connectivity from left aHP to the right TP. The same crossed-hemispheric coupling was found during rest, when people are left to their own thoughts. We conclude that (i) that the integration of episodic memory also supports the specific case of integrating context into empathic judgments, (ii) the right TP supports emotion processing by integrating episodic memory into empathic inferences, and (iii) lateral integration is a key process for episodic simulation during rest and during task. We propose that a disruption of the mechanism may underlie empathy deficits in clinical conditions, such as autism spectrum disorder. Nature Publishing Group UK 2018-06-20 /pmc/articles/PMC6010422/ /pubmed/29925874 http://dx.doi.org/10.1038/s41598-018-24557-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pehrs, Corinna Zaki, Jamil Taruffi, Liila Kuchinke, Lars Koelsch, Stefan Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition |
title | Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition |
title_full | Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition |
title_fullStr | Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition |
title_full_unstemmed | Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition |
title_short | Hippocampal-Temporopolar Connectivity Contributes to Episodic Simulation During Social Cognition |
title_sort | hippocampal-temporopolar connectivity contributes to episodic simulation during social cognition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010422/ https://www.ncbi.nlm.nih.gov/pubmed/29925874 http://dx.doi.org/10.1038/s41598-018-24557-y |
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