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Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior
Successful adaptation to complex environments depends on the balance of at least two systems: a flexible but slow goal-directed system encoding action-outcome associations and an efficient but rigid habitual system linking responses to preceding stimuli. Recent evidence suggests that the inferolater...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010441/ https://www.ncbi.nlm.nih.gov/pubmed/29925889 http://dx.doi.org/10.1038/s41598-018-27678-6 |
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author | Bogdanov, Mario Timmermann, Jan E. Gläscher, Jan Hummel, Friedhelm C. Schwabe, Lars |
author_facet | Bogdanov, Mario Timmermann, Jan E. Gläscher, Jan Hummel, Friedhelm C. Schwabe, Lars |
author_sort | Bogdanov, Mario |
collection | PubMed |
description | Successful adaptation to complex environments depends on the balance of at least two systems: a flexible but slow goal-directed system encoding action-outcome associations and an efficient but rigid habitual system linking responses to preceding stimuli. Recent evidence suggests that the inferolateral prefrontal cortex (ilPFC), a region well known to contribute to cognitive control processes, may play a crucial role in the balance of goal-directed and habitual responding. This evidence, however, comes mainly from correlational data and whether the ilPFC is indeed causally involved in the goal-directed vs. habitual control of behavior is unclear. Here, we used neuro-navigated theta-burst stimulation (TBS) to either inhibit or enhance right ilPFC functionality before participants completed an instrumental learning task designed to probe goal-directed vs. habitual behavioral control. TBS did not affect overall learning performance. However, participants that had received inhibitory TBS were less able to adapt their behavior to altered task demands, indicating a shift from goal-directed towards more habitual control of behavior. Sham or excitatory TMS groups showed no such effect and were comparable in their performance to an unstimulated control group. Our findings indicate a causal role of the ilPFC in the balance of goal-directed vs. habitual control of behavior. |
format | Online Article Text |
id | pubmed-6010441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60104412018-07-06 Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior Bogdanov, Mario Timmermann, Jan E. Gläscher, Jan Hummel, Friedhelm C. Schwabe, Lars Sci Rep Article Successful adaptation to complex environments depends on the balance of at least two systems: a flexible but slow goal-directed system encoding action-outcome associations and an efficient but rigid habitual system linking responses to preceding stimuli. Recent evidence suggests that the inferolateral prefrontal cortex (ilPFC), a region well known to contribute to cognitive control processes, may play a crucial role in the balance of goal-directed and habitual responding. This evidence, however, comes mainly from correlational data and whether the ilPFC is indeed causally involved in the goal-directed vs. habitual control of behavior is unclear. Here, we used neuro-navigated theta-burst stimulation (TBS) to either inhibit or enhance right ilPFC functionality before participants completed an instrumental learning task designed to probe goal-directed vs. habitual behavioral control. TBS did not affect overall learning performance. However, participants that had received inhibitory TBS were less able to adapt their behavior to altered task demands, indicating a shift from goal-directed towards more habitual control of behavior. Sham or excitatory TMS groups showed no such effect and were comparable in their performance to an unstimulated control group. Our findings indicate a causal role of the ilPFC in the balance of goal-directed vs. habitual control of behavior. Nature Publishing Group UK 2018-06-20 /pmc/articles/PMC6010441/ /pubmed/29925889 http://dx.doi.org/10.1038/s41598-018-27678-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bogdanov, Mario Timmermann, Jan E. Gläscher, Jan Hummel, Friedhelm C. Schwabe, Lars Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior |
title | Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior |
title_full | Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior |
title_fullStr | Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior |
title_full_unstemmed | Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior |
title_short | Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior |
title_sort | causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010441/ https://www.ncbi.nlm.nih.gov/pubmed/29925889 http://dx.doi.org/10.1038/s41598-018-27678-6 |
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