miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling

Expression of miR-143 and miR-145 is reduced in hematopoietic stem/progenitor cells (HSPCs) of myelodysplastic syndrome patients with a deletion in the long arm of chromosome 5. Here we show that mice lacking miR-143/145 have impaired HSPC activity with depletion of functional hematopoietic stem cel...

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Detalles Bibliográficos
Autores principales: Lam, Jeffrey, van den Bosch, Marion, Wegrzyn, Joanna, Parker, Jeremy, Ibrahim, Rawa, Slowski, Kate, Chang, Linda, Martinez-Høyer, Sergio, Condorelli, Gianluigi, Boldin, Mark, Deng, Yu, Umlandt, Patricia, Fuller, Megan, Karsan, Aly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010451/
https://www.ncbi.nlm.nih.gov/pubmed/29925839
http://dx.doi.org/10.1038/s41467-018-04831-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010451/
https://www.ncbi.nlm.nih.gov/pubmed/29925839
http://dx.doi.org/10.1038/s41467-018-04831-3

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