Cargando…

miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling

Expression of miR-143 and miR-145 is reduced in hematopoietic stem/progenitor cells (HSPCs) of myelodysplastic syndrome patients with a deletion in the long arm of chromosome 5. Here we show that mice lacking miR-143/145 have impaired HSPC activity with depletion of functional hematopoietic stem cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lam, Jeffrey, van den Bosch, Marion, Wegrzyn, Joanna, Parker, Jeremy, Ibrahim, Rawa, Slowski, Kate, Chang, Linda, Martinez-Høyer, Sergio, Condorelli, Gianluigi, Boldin, Mark, Deng, Yu, Umlandt, Patricia, Fuller, Megan, Karsan, Aly
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010451/ https://www.ncbi.nlm.nih.gov/pubmed/29925839 http://dx.doi.org/10.1038/s41467-018-04831-3

Ejemplares similares

TIRAP drives myelosuppression through an Ifnγ–Hmgb1 axis that disrupts the endothelial niche in mice
por: Gopal, Aparna, et al.
Publicado: (2022)

Identification of the canonical and noncanonical role of miR-143/145 in estrogen-deficient bone loss
por: Xu, Rongyao, et al.
Publicado: (2021)

MicroRNA-143/-145 in Cardiovascular Diseases
por: Zhao, Wang, et al.
Publicado: (2015)

rs41291957 controls miR‐143 and miR‐145 expression and impacts coronary artery disease risk
por: Hall, Ignacio Fernando, et al.
Publicado: (2021)

The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease
por: Elia, Leonardo, et al.
Publicado: (2009)

The differential expression of microRNA-143,145 in endometriosis
por: Zheng, Bingbing, et al.
Publicado: (2014)

Protocol for performing consecutive bone marrow transplants in mice to study the role of marrow niche in supporting hematopoiesis
por: Gopal, Aparna, et al.
Publicado: (2023)

Mir 145/143: tumor suppressor, oncogenic microenvironmental factor or …both?
por: Cioce, Mario, et al.
Publicado: (2016)

The Microrna-143/145 Cluster in Tumors: A Matter of Where and When
por: Poli, Valeria, et al.
Publicado: (2020)

The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease
por: Vacante, Francesca, et al.
Publicado: (2019)

TGF-β Induction of miR-143/145 Is Associated to Exercise Response by Influencing Differentiation and Insulin Signaling Molecules in Human Skeletal Muscle
por: Dreher, Simon I., et al.
Publicado: (2021)

Identification of non-coding RNAs embracing microRNA-143/145 cluster
por: Iio, Akio, et al.
Publicado: (2010)

Clinicopathological Significance of microRNA-31, -143 and -145 Expression in Colorectal Cancer
por: Wang, Chao-Jie, et al.
Publicado: (2009)

MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis
por: Hong, Bong-Ki, et al.
Publicado: (2017)

Regulation of intraocular pressure by microRNA cluster miR-143/145
por: Li, Xinyu, et al.
Publicado: (2017)

The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles
por: Almeida, Maria Inês, et al.
Publicado: (2016)

Epigenetic regulation of MIR145 core promoter controls miR-143/145 cluster in bladder cancer progression and treatment outcome
por: Pilala, Katerina-Marina, et al.
Publicado: (2022)

ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
por: Zhou, Qiling, et al.
Publicado: (2021)

The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer
por: Villadsen, S B, et al.
Publicado: (2012)

miR-145 and miR-143 Regulate Smooth Muscle Cell Fate Decisions
por: Cordes, Kimberly R., et al.
Publicado: (2009)

Lessons from miR-143/145: the importance of cell-type localization of miRNAs
por: Kent, Oliver A., et al.
Publicado: (2014)

Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer
por: Johannessen, Charles, et al.
Publicado: (2017)

Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms
por: Lecoutre, Simon, et al.
Publicado: (2022)

Identification of miRs-143 and -145 that Is Associated with Bone Metastasis of Prostate Cancer and Involved in the Regulation of EMT
por: Peng, Xinsheng, et al.
Publicado: (2011)

Implications of miR cluster 143/145 as universal anti-oncomiRs and their dysregulation during tumorigenesis
por: Das, Ani V., et al.
Publicado: (2015)

Flank Sequences of miR‐145/143 and Their Aberrant Expression in Vascular Disease: Mechanism and Therapeutic Application
por: Liu, Xiaojun, et al.
Publicado: (2013)

c-Myb regulates transcriptional activation of miR-143/145 in vascular smooth muscle cells
por: Chandy, Mark, et al.
Publicado: (2018)

Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of intracranial aneurysm
por: Sima, Xiutian, et al.
Publicado: (2017)

Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia
por: Liu, Kejian, et al.
Publicado: (2017)

Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift
por: Ogawa, Kota, et al.
Publicado: (2020)

Serial selection for invasiveness increases expression of miR-143/miR-145 in glioblastoma cell lines
por: Koo, Sunwoo, et al.
Publicado: (2012)

High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage
por: Wang, Yiting, et al.
Publicado: (2019)

MiR-143 and MiR-145 Regulate IGF1R to Suppress Cell Proliferation in Colorectal Cancer
por: Su, Jiaojiao, et al.
Publicado: (2014)

An rs4705342 T>C polymorphism in the promoter of miR-143/145 is associated with a decreased risk of ischemic stroke
por: Wei, Ye-Sheng, et al.
Publicado: (2016)

miR-143 and miR-145 inhibit gastric cancer cell migration and metastasis by suppressing MYO6
por: Lei, Chao, et al.
Publicado: (2017)

A polymorphism rs4705341 in the flanking region of miR-143/145 predicts risk and prognosis of colorectal cancer
por: Sun, Ruifen, et al.
Publicado: (2016)

A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer
por: Yuan, Fang, et al.
Publicado: (2016)

The diagnostic value of miR-92a, -143, and -145 expression levels in patients with colorectal adenocarcinoma from Romania
por: Brînzan, Costel, et al.
Publicado: (2020)

Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma
por: Diazzi, Serena, et al.
Publicado: (2022)

Prognostic value of micro-RNA 375, 133, 143, 145 in esophageal carcinoma: A systematic review and meta-analysis
por: Fang, Pinhao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cssic2a4m6bdii0m9uhhu88f2d