Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors

Cell-to-cell differences in protein expression in normal tissues and tumors are a common phenomenon, but the underlying principles that govern this heterogeneity are largely unknown. Here, we show that in monolayer cancer cell-line cultures, the expression of the five metabolic enzymes of serine-gly...

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Detalles Bibliográficos
Autores principales: Singh, Manjulata, Warita, Katsuhiko, Warita, Tomoko, Faeder, James R., Lee, Robin E. C., Sant, Shilpa, Oltvai, Zoltán N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010463/
https://www.ncbi.nlm.nih.gov/pubmed/29925909
http://dx.doi.org/10.1038/s41598-018-27266-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010463/
https://www.ncbi.nlm.nih.gov/pubmed/29925909
http://dx.doi.org/10.1038/s41598-018-27266-8

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