Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer

PURPOSE: Preclinical research and prior clinical observations demonstrated reduced toxicity and suggested enhanced efficacy of cisplatin due to folic acid and vitamin B12 suppletion. In this randomized phase 2 trial, we evaluated the addition of folic acid and vitamin B12 to first-line palliative ci...

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Detalles Bibliográficos
Autores principales: van Zweeden, A. A., van Groeningen, C. J., Honeywell, R. J., Giovannetti, E., Ruijter, R., Smorenburg, C. H., Giaccone, G., Verheul, H. M. W., Peters, G. J., van der Vliet, Hans J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010482/
https://www.ncbi.nlm.nih.gov/pubmed/29696360
http://dx.doi.org/10.1007/s00280-018-3588-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010482/
https://www.ncbi.nlm.nih.gov/pubmed/29696360
http://dx.doi.org/10.1007/s00280-018-3588-6

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