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Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens

We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this technology toward the discovery of anti-resistance molecules, focusing on efflux pump inhibitors. Using high-throughput screening against multi-drug...

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Detalles Bibliográficos
Autores principales:	Fleeman, Renee M., Debevec, Ginamarie, Antonen, Kirsten, Adams, Jessie L., Santos, Radleigh G., Welmaker, Gregory S., Houghten, Richard A., Giulianotti, Marc A., Shaw, Lindsey N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010545/ https://www.ncbi.nlm.nih.gov/pubmed/29963035 http://dx.doi.org/10.3389/fmicb.2018.01301

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