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Good's syndrome with clinical manifestation after thymectomy: A case report
Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. A 74-year-old Japanese woman underwent total thymothymectomy for type AB thymoma (2015 WHO classification). She developed recurrent infectious diseases caused by Escherichia coli...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010670/ https://www.ncbi.nlm.nih.gov/pubmed/29977769 http://dx.doi.org/10.1016/j.rmcr.2018.04.014 |
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author | Furukawa, Ryutaro Yanagiya, Masahiro Matsumoto, Jun Hashimoto, Hirotsugu Horiuchi, Hajime Usui, Kazuhiro |
author_facet | Furukawa, Ryutaro Yanagiya, Masahiro Matsumoto, Jun Hashimoto, Hirotsugu Horiuchi, Hajime Usui, Kazuhiro |
author_sort | Furukawa, Ryutaro |
collection | PubMed |
description | Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. A 74-year-old Japanese woman underwent total thymothymectomy for type AB thymoma (2015 WHO classification). She developed recurrent infectious diseases caused by Escherichia coli (bacteremia), Streptococcus pneumoniae (pneumonia and bacteremia) and Pseudomonas aeruginosa (bacteremia) in the year after thymectomy. The serum levels of immunoglobulin were significantly low (IgG 157mg/dL), which suggested that her infectious diseases were associated with Good's syndrome. Although she began receiving intravenous immunoglobulin every four weeks, she died of pneumonia a week after the second administration of immunoglobulin. When physicians encounter patients with recurrent infection who have a medical history of thymoma, the detection of hypogammaglubulinemia can be a key clue to the diagnosis of Good's syndrome. |
format | Online Article Text |
id | pubmed-6010670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60106702018-07-05 Good's syndrome with clinical manifestation after thymectomy: A case report Furukawa, Ryutaro Yanagiya, Masahiro Matsumoto, Jun Hashimoto, Hirotsugu Horiuchi, Hajime Usui, Kazuhiro Respir Med Case Rep Case Report Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. A 74-year-old Japanese woman underwent total thymothymectomy for type AB thymoma (2015 WHO classification). She developed recurrent infectious diseases caused by Escherichia coli (bacteremia), Streptococcus pneumoniae (pneumonia and bacteremia) and Pseudomonas aeruginosa (bacteremia) in the year after thymectomy. The serum levels of immunoglobulin were significantly low (IgG 157mg/dL), which suggested that her infectious diseases were associated with Good's syndrome. Although she began receiving intravenous immunoglobulin every four weeks, she died of pneumonia a week after the second administration of immunoglobulin. When physicians encounter patients with recurrent infection who have a medical history of thymoma, the detection of hypogammaglubulinemia can be a key clue to the diagnosis of Good's syndrome. Elsevier 2018-04-27 /pmc/articles/PMC6010670/ /pubmed/29977769 http://dx.doi.org/10.1016/j.rmcr.2018.04.014 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Furukawa, Ryutaro Yanagiya, Masahiro Matsumoto, Jun Hashimoto, Hirotsugu Horiuchi, Hajime Usui, Kazuhiro Good's syndrome with clinical manifestation after thymectomy: A case report |
title | Good's syndrome with clinical manifestation after thymectomy: A case report |
title_full | Good's syndrome with clinical manifestation after thymectomy: A case report |
title_fullStr | Good's syndrome with clinical manifestation after thymectomy: A case report |
title_full_unstemmed | Good's syndrome with clinical manifestation after thymectomy: A case report |
title_short | Good's syndrome with clinical manifestation after thymectomy: A case report |
title_sort | good's syndrome with clinical manifestation after thymectomy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010670/ https://www.ncbi.nlm.nih.gov/pubmed/29977769 http://dx.doi.org/10.1016/j.rmcr.2018.04.014 |
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