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Good's syndrome with clinical manifestation after thymectomy: A case report

Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. A 74-year-old Japanese woman underwent total thymothymectomy for type AB thymoma (2015 WHO classification). She developed recurrent infectious diseases caused by Escherichia coli...

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Autores principales: Furukawa, Ryutaro, Yanagiya, Masahiro, Matsumoto, Jun, Hashimoto, Hirotsugu, Horiuchi, Hajime, Usui, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010670/
https://www.ncbi.nlm.nih.gov/pubmed/29977769
http://dx.doi.org/10.1016/j.rmcr.2018.04.014
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author Furukawa, Ryutaro
Yanagiya, Masahiro
Matsumoto, Jun
Hashimoto, Hirotsugu
Horiuchi, Hajime
Usui, Kazuhiro
author_facet Furukawa, Ryutaro
Yanagiya, Masahiro
Matsumoto, Jun
Hashimoto, Hirotsugu
Horiuchi, Hajime
Usui, Kazuhiro
author_sort Furukawa, Ryutaro
collection PubMed
description Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. A 74-year-old Japanese woman underwent total thymothymectomy for type AB thymoma (2015 WHO classification). She developed recurrent infectious diseases caused by Escherichia coli (bacteremia), Streptococcus pneumoniae (pneumonia and bacteremia) and Pseudomonas aeruginosa (bacteremia) in the year after thymectomy. The serum levels of immunoglobulin were significantly low (IgG 157mg/dL), which suggested that her infectious diseases were associated with Good's syndrome. Although she began receiving intravenous immunoglobulin every four weeks, she died of pneumonia a week after the second administration of immunoglobulin. When physicians encounter patients with recurrent infection who have a medical history of thymoma, the detection of hypogammaglubulinemia can be a key clue to the diagnosis of Good's syndrome.
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spelling pubmed-60106702018-07-05 Good's syndrome with clinical manifestation after thymectomy: A case report Furukawa, Ryutaro Yanagiya, Masahiro Matsumoto, Jun Hashimoto, Hirotsugu Horiuchi, Hajime Usui, Kazuhiro Respir Med Case Rep Case Report Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. A 74-year-old Japanese woman underwent total thymothymectomy for type AB thymoma (2015 WHO classification). She developed recurrent infectious diseases caused by Escherichia coli (bacteremia), Streptococcus pneumoniae (pneumonia and bacteremia) and Pseudomonas aeruginosa (bacteremia) in the year after thymectomy. The serum levels of immunoglobulin were significantly low (IgG 157mg/dL), which suggested that her infectious diseases were associated with Good's syndrome. Although she began receiving intravenous immunoglobulin every four weeks, she died of pneumonia a week after the second administration of immunoglobulin. When physicians encounter patients with recurrent infection who have a medical history of thymoma, the detection of hypogammaglubulinemia can be a key clue to the diagnosis of Good's syndrome. Elsevier 2018-04-27 /pmc/articles/PMC6010670/ /pubmed/29977769 http://dx.doi.org/10.1016/j.rmcr.2018.04.014 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Furukawa, Ryutaro
Yanagiya, Masahiro
Matsumoto, Jun
Hashimoto, Hirotsugu
Horiuchi, Hajime
Usui, Kazuhiro
Good's syndrome with clinical manifestation after thymectomy: A case report
title Good's syndrome with clinical manifestation after thymectomy: A case report
title_full Good's syndrome with clinical manifestation after thymectomy: A case report
title_fullStr Good's syndrome with clinical manifestation after thymectomy: A case report
title_full_unstemmed Good's syndrome with clinical manifestation after thymectomy: A case report
title_short Good's syndrome with clinical manifestation after thymectomy: A case report
title_sort good's syndrome with clinical manifestation after thymectomy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010670/
https://www.ncbi.nlm.nih.gov/pubmed/29977769
http://dx.doi.org/10.1016/j.rmcr.2018.04.014
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