Durable engraftment of genetically modified FVIII‐secreting autologous bone marrow stromal cells in the intramedullary microenvironment

Genetically modified FVIII‐expressing autologous bone marrow‐derived mesenchymal stromal cells (BMSCs) could cure haemophilia A. However, culture‐expanded BMSCs engraft poorly in extramedullary sites. Here, we compared the intramedullary cavity, skeletal muscle, subcutaneous tissue and systemic circ...

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Detalles Bibliográficos
Autores principales: Lee, Sze Sing, Sivalingam, Jaichandran, Nirmal, Ajit J., Ng, Wai Har, Kee, Irene, Song, In Chin, Kiong, Chin Yong, Gales, Kristoffer A., Chua, Frederic, Pena, Edgar M., Ogden, Bryan E., Kon, Oi Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010829/
https://www.ncbi.nlm.nih.gov/pubmed/29682884
http://dx.doi.org/10.1111/jcmm.13648

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