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Anti‐PD‐1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases

Osteosarcoma (OS) pulmonary metastasis translates into poor patient survival. The implication of PD‐1‐PD‐L1 pathway in the context of NK cells and/or macrophages in OS is unknown. We investigated the effect of anti‐PD‐1 in OS lung metastasis and the role of NK cells and/or macrophages in anti‐PD‐1 r...

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Detalles Bibliográficos
Autores principales:	Dhupkar, Pooja, Gordon, Nancy, Stewart, John, Kleinerman, Eugenie S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010882/ https://www.ncbi.nlm.nih.gov/pubmed/29733528 http://dx.doi.org/10.1002/cam4.1518

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