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TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer

Tumour protein p53‐inducible nuclear protein 1 (TP53INP1) is a tumour suppressor associated with malignant tumour metastasis. Vasculogenic mimicry (VM) is a new tumour vascular supply pattern that significantly influences tumour metastasis and contributes to a poor prognosis. However, the molecular...

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Autores principales: Wang, Yi, Sun, Huizhi, Zhang, Danfang, Fan, Dan, Zhang, Yanhui, Dong, Xueyi, Liu, Shiqi, Yang, Zhao, Ni, Chunsheng, Li, Yanlei, Liu, Fang, Zhao, Xiulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010892/
https://www.ncbi.nlm.nih.gov/pubmed/29655255
http://dx.doi.org/10.1111/jcmm.13625
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author Wang, Yi
Sun, Huizhi
Zhang, Danfang
Fan, Dan
Zhang, Yanhui
Dong, Xueyi
Liu, Shiqi
Yang, Zhao
Ni, Chunsheng
Li, Yanlei
Liu, Fang
Zhao, Xiulan
author_facet Wang, Yi
Sun, Huizhi
Zhang, Danfang
Fan, Dan
Zhang, Yanhui
Dong, Xueyi
Liu, Shiqi
Yang, Zhao
Ni, Chunsheng
Li, Yanlei
Liu, Fang
Zhao, Xiulan
author_sort Wang, Yi
collection PubMed
description Tumour protein p53‐inducible nuclear protein 1 (TP53INP1) is a tumour suppressor associated with malignant tumour metastasis. Vasculogenic mimicry (VM) is a new tumour vascular supply pattern that significantly influences tumour metastasis and contributes to a poor prognosis. However, the molecular mechanism of the relationship between TP53INP1 and breast cancer VM formation is unknown. Here, we explored the underlying mechanism by which TP53INP1 regulates VM formation in vitro and in vivo. High TP53INP1 expression was not only negatively correlated with a poor prognosis but also had a negative relationship with VE‐cadherin, HIF‐1α and Snail expression. TP53INP1 overexpression inhibited breast cancer invasion, migration, epithelial‐mesenchymal transition (EMT) and VM formation; conversely, TP53INP1 down‐regulation promoted these processes in vitro by functional experiments and Western blot analysis. We established a hypoxia model induced by CoCl(2) and assessed the effects of TP53INP1 on hypoxia‐induced EMT and VM formation. In addition, we confirmed that a reactive oxygen species (ROS)‐mediated signalling pathway participated in TP53INP1‐mediated VM formation. Together, our results show that TP53INP1 inhibits hypoxia‐induced EMT and VM formation via the ROS/GSK‐3β/Snail pathway in breast cancer, which offers new insights into breast cancer clinical therapy.
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spelling pubmed-60108922018-07-01 TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer Wang, Yi Sun, Huizhi Zhang, Danfang Fan, Dan Zhang, Yanhui Dong, Xueyi Liu, Shiqi Yang, Zhao Ni, Chunsheng Li, Yanlei Liu, Fang Zhao, Xiulan J Cell Mol Med Original Articles Tumour protein p53‐inducible nuclear protein 1 (TP53INP1) is a tumour suppressor associated with malignant tumour metastasis. Vasculogenic mimicry (VM) is a new tumour vascular supply pattern that significantly influences tumour metastasis and contributes to a poor prognosis. However, the molecular mechanism of the relationship between TP53INP1 and breast cancer VM formation is unknown. Here, we explored the underlying mechanism by which TP53INP1 regulates VM formation in vitro and in vivo. High TP53INP1 expression was not only negatively correlated with a poor prognosis but also had a negative relationship with VE‐cadherin, HIF‐1α and Snail expression. TP53INP1 overexpression inhibited breast cancer invasion, migration, epithelial‐mesenchymal transition (EMT) and VM formation; conversely, TP53INP1 down‐regulation promoted these processes in vitro by functional experiments and Western blot analysis. We established a hypoxia model induced by CoCl(2) and assessed the effects of TP53INP1 on hypoxia‐induced EMT and VM formation. In addition, we confirmed that a reactive oxygen species (ROS)‐mediated signalling pathway participated in TP53INP1‐mediated VM formation. Together, our results show that TP53INP1 inhibits hypoxia‐induced EMT and VM formation via the ROS/GSK‐3β/Snail pathway in breast cancer, which offers new insights into breast cancer clinical therapy. John Wiley and Sons Inc. 2018-04-14 2018-07 /pmc/articles/PMC6010892/ /pubmed/29655255 http://dx.doi.org/10.1111/jcmm.13625 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Wang, Yi
Sun, Huizhi
Zhang, Danfang
Fan, Dan
Zhang, Yanhui
Dong, Xueyi
Liu, Shiqi
Yang, Zhao
Ni, Chunsheng
Li, Yanlei
Liu, Fang
Zhao, Xiulan
TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer
title TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer
title_full TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer
title_fullStr TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer
title_full_unstemmed TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer
title_short TP53INP1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer
title_sort tp53inp1 inhibits hypoxia‐induced vasculogenic mimicry formation via the ros/snail signalling axis in breast cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010892/
https://www.ncbi.nlm.nih.gov/pubmed/29655255
http://dx.doi.org/10.1111/jcmm.13625
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