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The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling

Rationale: Lapatinib (LAP) is a crucial alternative to trastuzumab upon the onset of drug resistance during treatment of metastatic human epidermal growth factor receptor 2-positive breast cancer. Like trastuzumab, LAP is commonly used alongside anthracyclines as a combination therapy, due to enhanc...

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Detalles Bibliográficos
Autores principales:	Hsu, Wan-Tseng, Huang, Ching-Ying, Yen, Christopher Y.T., Cheng, Ann-Lii, Hsieh, Patrick C.H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010982/ https://www.ncbi.nlm.nih.gov/pubmed/29930721 http://dx.doi.org/10.7150/thno.23207

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