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Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been...

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Detalles Bibliográficos
Autores principales:	Johnsen, Kasper Bendix, Bak, Martin, Kempen, Paul Joseph, Melander, Fredrik, Burkhart, Annette, Thomsen, Maj Schneider, Nielsen, Morten Schallburg, Moos, Torben, Andresen, Thomas Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010987/ https://www.ncbi.nlm.nih.gov/pubmed/29930740 http://dx.doi.org/10.7150/thno.25228

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