QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes

Type II dehydroquinase enzymes (DHQ2), recognized targets for antibiotic drug discovery, show significantly different activities dependent on the species: DHQ2 from Mycobacterium tuberculosis (MtDHQ2) and Helicobacter pylori (HpDHQ2) show a 50-fold difference in catalytic efficiency. Revealing the d...

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Detalles Bibliográficos
Autores principales: Lence, Emilio, van der Kamp, Marc W., González-Bello, Concepción, Mulholland, Adrian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011038/
https://www.ncbi.nlm.nih.gov/pubmed/29767194
http://dx.doi.org/10.1039/c8ob00066b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011038/
https://www.ncbi.nlm.nih.gov/pubmed/29767194
http://dx.doi.org/10.1039/c8ob00066b

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