Wee1 Inhibitor AZD1775 Combined with Cisplatin Potentiates Anticancer Activity against Gastric Cancer by Increasing DNA Damage and Cell Apoptosis

Based on the mechanisms by which Wee1 inhibitor and cisplatin played their own role, a promising strategy of Wee1 inhibitor combined with cisplatin was proposed, which was investigated in gastric cancer (GC). Either Wee1 inhibitor AZD1775 or cisplatin alone had a certain inhibitory effect on in vitr...

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Detalles Bibliográficos
Autores principales: Chen, Dongshao, Lin, Xiaoting, Gao, Jing, Shen, Lin, Li, Zhongwu, Dong, Bin, Zhang, Cheng, Zhang, Xiaotian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011131/
https://www.ncbi.nlm.nih.gov/pubmed/29977914
http://dx.doi.org/10.1155/2018/5813292

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