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Never Too Old? Occurrence of Medulloblastoma in the Elderly beyond the 70th Year of Life

The occurrence of medulloblastoma (MB) in the elderly is an absolutely rare event. Concerning this issue we report on two MB patients beyond the 70th year of life. Two patients older than 70 years presented with a mass in the posterior fossa without evidence of a preexisting malignant tumor. After c...

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Autores principales: Maslehaty, Homajoun, Van de Nes, Johannes, Teuber-Hanselmann, Sarah, Moenninghoff, Christoph, Sure, Ulrich, Oezkan, Neriman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011152/
https://www.ncbi.nlm.nih.gov/pubmed/29984017
http://dx.doi.org/10.1155/2018/8639404
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author Maslehaty, Homajoun
Van de Nes, Johannes
Teuber-Hanselmann, Sarah
Moenninghoff, Christoph
Sure, Ulrich
Oezkan, Neriman
author_facet Maslehaty, Homajoun
Van de Nes, Johannes
Teuber-Hanselmann, Sarah
Moenninghoff, Christoph
Sure, Ulrich
Oezkan, Neriman
author_sort Maslehaty, Homajoun
collection PubMed
description The occurrence of medulloblastoma (MB) in the elderly is an absolutely rare event. Concerning this issue we report on two MB patients beyond the 70th year of life. Two patients older than 70 years presented with a mass in the posterior fossa without evidence of a preexisting malignant tumor. After careful radiological work-up the suspected diagnosis was metastasis of an unknown primary tumor. Both patients underwent surgery and histopathological analysis revealed MB in both cases (classical MB and desmoplastic type). The two cases presented here represent also one classical MB and one additional desmoplastic MB. To our knowledge we report for the first time that there are different molecular subtypes of MB in the elderly patients that seem to be consistent with those subtypes mainly occurring in young adults. Unfortunately the patients died within one week after surgery due to respiratory insufficiency and an unclear cause. The presented cases show that MB can occur in the elderly. Although this constellation is absolutely rare, MB should be considered in the differential diagnosis, especially when a primary tumor is not known or detected.
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spelling pubmed-60111522018-07-08 Never Too Old? Occurrence of Medulloblastoma in the Elderly beyond the 70th Year of Life Maslehaty, Homajoun Van de Nes, Johannes Teuber-Hanselmann, Sarah Moenninghoff, Christoph Sure, Ulrich Oezkan, Neriman Case Rep Neurol Med Case Report The occurrence of medulloblastoma (MB) in the elderly is an absolutely rare event. Concerning this issue we report on two MB patients beyond the 70th year of life. Two patients older than 70 years presented with a mass in the posterior fossa without evidence of a preexisting malignant tumor. After careful radiological work-up the suspected diagnosis was metastasis of an unknown primary tumor. Both patients underwent surgery and histopathological analysis revealed MB in both cases (classical MB and desmoplastic type). The two cases presented here represent also one classical MB and one additional desmoplastic MB. To our knowledge we report for the first time that there are different molecular subtypes of MB in the elderly patients that seem to be consistent with those subtypes mainly occurring in young adults. Unfortunately the patients died within one week after surgery due to respiratory insufficiency and an unclear cause. The presented cases show that MB can occur in the elderly. Although this constellation is absolutely rare, MB should be considered in the differential diagnosis, especially when a primary tumor is not known or detected. Hindawi 2018-06-07 /pmc/articles/PMC6011152/ /pubmed/29984017 http://dx.doi.org/10.1155/2018/8639404 Text en Copyright © 2018 Homajoun Maslehaty et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Maslehaty, Homajoun
Van de Nes, Johannes
Teuber-Hanselmann, Sarah
Moenninghoff, Christoph
Sure, Ulrich
Oezkan, Neriman
Never Too Old? Occurrence of Medulloblastoma in the Elderly beyond the 70th Year of Life
title Never Too Old? Occurrence of Medulloblastoma in the Elderly beyond the 70th Year of Life
title_full Never Too Old? Occurrence of Medulloblastoma in the Elderly beyond the 70th Year of Life
title_fullStr Never Too Old? Occurrence of Medulloblastoma in the Elderly beyond the 70th Year of Life
title_full_unstemmed Never Too Old? Occurrence of Medulloblastoma in the Elderly beyond the 70th Year of Life
title_short Never Too Old? Occurrence of Medulloblastoma in the Elderly beyond the 70th Year of Life
title_sort never too old? occurrence of medulloblastoma in the elderly beyond the 70th year of life
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011152/
https://www.ncbi.nlm.nih.gov/pubmed/29984017
http://dx.doi.org/10.1155/2018/8639404
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