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Effect of zolpidem on functional recovery in a rat model of ischemic stroke

OBJECTIVE: To evaluate the effects of zolpidem on functional recovery in a rat model of acute ischemic stroke. METHODS: Following ischemic stroke procedures, 42 rats (six in each group) were randomly assigned to receive zolpidem (0.1, 0.25, 0.5, 1.0, 2.0 or 4.0 mg/kg) or normal saline administer int...

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Autores principales: Oh, Min-Kyun, Yoon, Kyung Jae, Lee, Yong-Taek, Chae, Seoung Wan, Choi, Hye Young, Shin, Hee Suk, Park, Yun Hee, Chun, Se-Woong, Park, Young Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011331/
https://www.ncbi.nlm.nih.gov/pubmed/28831822
http://dx.doi.org/10.1177/0300060517723799
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author Oh, Min-Kyun
Yoon, Kyung Jae
Lee, Yong-Taek
Chae, Seoung Wan
Choi, Hye Young
Shin, Hee Suk
Park, Yun Hee
Chun, Se-Woong
Park, Young Sook
author_facet Oh, Min-Kyun
Yoon, Kyung Jae
Lee, Yong-Taek
Chae, Seoung Wan
Choi, Hye Young
Shin, Hee Suk
Park, Yun Hee
Chun, Se-Woong
Park, Young Sook
author_sort Oh, Min-Kyun
collection PubMed
description OBJECTIVE: To evaluate the effects of zolpidem on functional recovery in a rat model of acute ischemic stroke. METHODS: Following ischemic stroke procedures, 42 rats (six in each group) were randomly assigned to receive zolpidem (0.1, 0.25, 0.5, 1.0, 2.0 or 4.0 mg/kg) or normal saline administer intraperitoneally once daily for two weeks. Motor behavioural index (MBI) scores, radial 8-arm maze (RAM) test times and brain MRI scans were obtained 24 hours (Day 1) and two weeks (Day 14) post-procedure. Immunohistochemistry was performed on Day 14. RESULTS: By comparison with the normal saline group, the 0.5 and 1.0 mg/kg zolpidem groups showed statistically significant improvements in MBI scores and increased numbers of brain-derived neurotrophic factor (BDNF) stained cells over the two week dosing period. By contrast, the 4.0 mg/kg zolpidem group had statistically significantly impaired MBI scores compared with the control group. No differences among groups were found in RAM times or infarction volumes. CONCLUSIONS: This study in a rat model showed that 0.5–1.0 mg/kg of zolpidem had beneficial effects on behavioural recovery by enhancing neural plasticity without causing any memory impairment in acute ischemic stroke.
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spelling pubmed-60113312018-06-25 Effect of zolpidem on functional recovery in a rat model of ischemic stroke Oh, Min-Kyun Yoon, Kyung Jae Lee, Yong-Taek Chae, Seoung Wan Choi, Hye Young Shin, Hee Suk Park, Yun Hee Chun, Se-Woong Park, Young Sook J Int Med Res Research Report OBJECTIVE: To evaluate the effects of zolpidem on functional recovery in a rat model of acute ischemic stroke. METHODS: Following ischemic stroke procedures, 42 rats (six in each group) were randomly assigned to receive zolpidem (0.1, 0.25, 0.5, 1.0, 2.0 or 4.0 mg/kg) or normal saline administer intraperitoneally once daily for two weeks. Motor behavioural index (MBI) scores, radial 8-arm maze (RAM) test times and brain MRI scans were obtained 24 hours (Day 1) and two weeks (Day 14) post-procedure. Immunohistochemistry was performed on Day 14. RESULTS: By comparison with the normal saline group, the 0.5 and 1.0 mg/kg zolpidem groups showed statistically significant improvements in MBI scores and increased numbers of brain-derived neurotrophic factor (BDNF) stained cells over the two week dosing period. By contrast, the 4.0 mg/kg zolpidem group had statistically significantly impaired MBI scores compared with the control group. No differences among groups were found in RAM times or infarction volumes. CONCLUSIONS: This study in a rat model showed that 0.5–1.0 mg/kg of zolpidem had beneficial effects on behavioural recovery by enhancing neural plasticity without causing any memory impairment in acute ischemic stroke. SAGE Publications 2017-08-23 2018-01 /pmc/articles/PMC6011331/ /pubmed/28831822 http://dx.doi.org/10.1177/0300060517723799 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Report
Oh, Min-Kyun
Yoon, Kyung Jae
Lee, Yong-Taek
Chae, Seoung Wan
Choi, Hye Young
Shin, Hee Suk
Park, Yun Hee
Chun, Se-Woong
Park, Young Sook
Effect of zolpidem on functional recovery in a rat model of ischemic stroke
title Effect of zolpidem on functional recovery in a rat model of ischemic stroke
title_full Effect of zolpidem on functional recovery in a rat model of ischemic stroke
title_fullStr Effect of zolpidem on functional recovery in a rat model of ischemic stroke
title_full_unstemmed Effect of zolpidem on functional recovery in a rat model of ischemic stroke
title_short Effect of zolpidem on functional recovery in a rat model of ischemic stroke
title_sort effect of zolpidem on functional recovery in a rat model of ischemic stroke
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011331/
https://www.ncbi.nlm.nih.gov/pubmed/28831822
http://dx.doi.org/10.1177/0300060517723799
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