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Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy

Bcr-Abl inhibitors paved the way of targeted therapy epoch. Imatinib was the first tyrosine kinase inhibitor to be discovered with high specificity for Bcr-Abl protein resulting from t(9, 22)-derived Philadelphia chromosome. Although the specific targeting of that oncoprotein, several Bcr-Abl-depend...

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Detalles Bibliográficos
Autores principales:	Rossari, Federico, Minutolo, Filippo, Orciuolo, Enrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011351/ https://www.ncbi.nlm.nih.gov/pubmed/29925402 http://dx.doi.org/10.1186/s13045-018-0624-2

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