Cargando…
Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies
BACKGROUND: Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes. NK cells and T-lymphocytes mediate early killing of targets through a common granzyme B-dependent mechanism. Tumor cell resi...
Autores principales: | Friedman, Jay, Morisada, Megan, Sun, Lillian, Moore, Ellen C., Padget, Michelle, Hodge, James W., Schlom, Jeffrey, Gameiro, Sofia R., Allen, Clint T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011473/ https://www.ncbi.nlm.nih.gov/pubmed/29925431 http://dx.doi.org/10.1186/s40425-018-0374-2 |
Ejemplares similares
-
Chimeric antigen receptor engineered NK cellular immunotherapy overcomes the selection of T-cell escape variant cancer cells
por: Lee, Maxwell Y, et al.
Publicado: (2021) -
A Wee1 checkpoint inhibits anaphase onset
por: Lianga, Noel, et al.
Publicado: (2013) -
Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells
por: Robbins, Yvette, et al.
Publicado: (2020) -
Combined Inhibition of IAPs and WEE1 Enhances TNFα- and Radiation-Induced Cell Death in Head and Neck Squamous Carcinoma
por: Toni, Tiffany, et al.
Publicado: (2023) -
Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells
por: Clavijo, Paul E., et al.
Publicado: (2017)