Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing?

Prostate-specific membrane antigen (PSMA) expression has been shown in neovasculature of various malignancies. Recurrent medullary thyroid cancer (MTC) is difficult to treat. We present the findings on PSMA-positron emission tomography/computed tomography (PET/CT) of a 68-year-old man with MTC, who...

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Autores principales: Arora, Saurabh, Prabhu, Meghana, Damle, Nishikant Avinash, Bal, Chandrasekhar, Kumar, Praveen, Nalla, Harish, Arun Raj, Sreedharan Thankarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Interesting Image
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011559/
https://www.ncbi.nlm.nih.gov/pubmed/29962733
http://dx.doi.org/10.4103/ijnm.IJNM_10_18
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author Arora, Saurabh
Prabhu, Meghana
Damle, Nishikant Avinash
Bal, Chandrasekhar
Kumar, Praveen
Nalla, Harish
Arun Raj, Sreedharan Thankarajan
author_facet Arora, Saurabh
Prabhu, Meghana
Damle, Nishikant Avinash
Bal, Chandrasekhar
Kumar, Praveen
Nalla, Harish
Arun Raj, Sreedharan Thankarajan
author_sort Arora, Saurabh
collection PubMed
description Prostate-specific membrane antigen (PSMA) expression has been shown in neovasculature of various malignancies. Recurrent medullary thyroid cancer (MTC) is difficult to treat. We present the findings on PSMA-positron emission tomography/computed tomography (PET/CT) of a 68-year-old man with MTC, who presented with a recurrent left paratracheal mass and rising calcitonin. The scan revealed significant uptake on PSMA imaging but not on (68)Ga-DOTANOC PET/CT. (177)Lu-PRRT is one of the therapeutic options in patients with recurrent MTC, but in this case was not possible due to lack of somatostatin receptor expression. Imaging evidence of PSMA expression alerts us to the potential use of (177)Lu-DKFZ-PSMA-617 therapy in such patients.
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spelling pubmed-60115592018-07-01 Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing? Arora, Saurabh Prabhu, Meghana Damle, Nishikant Avinash Bal, Chandrasekhar Kumar, Praveen Nalla, Harish Arun Raj, Sreedharan Thankarajan Indian J Nucl Med Interesting Image Prostate-specific membrane antigen (PSMA) expression has been shown in neovasculature of various malignancies. Recurrent medullary thyroid cancer (MTC) is difficult to treat. We present the findings on PSMA-positron emission tomography/computed tomography (PET/CT) of a 68-year-old man with MTC, who presented with a recurrent left paratracheal mass and rising calcitonin. The scan revealed significant uptake on PSMA imaging but not on (68)Ga-DOTANOC PET/CT. (177)Lu-PRRT is one of the therapeutic options in patients with recurrent MTC, but in this case was not possible due to lack of somatostatin receptor expression. Imaging evidence of PSMA expression alerts us to the potential use of (177)Lu-DKFZ-PSMA-617 therapy in such patients. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6011559/ /pubmed/29962733 http://dx.doi.org/10.4103/ijnm.IJNM_10_18 Text en Copyright: © 2018 Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Interesting Image
Arora, Saurabh
Prabhu, Meghana
Damle, Nishikant Avinash
Bal, Chandrasekhar
Kumar, Praveen
Nalla, Harish
Arun Raj, Sreedharan Thankarajan
Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing?
title Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing?
title_full Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing?
title_fullStr Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing?
title_full_unstemmed Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing?
title_short Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing?
title_sort prostate-specific membrane antigen imaging in recurrent medullary thyroid cancer: a new theranostic tracer in the offing?
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011559/
https://www.ncbi.nlm.nih.gov/pubmed/29962733
http://dx.doi.org/10.4103/ijnm.IJNM_10_18
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