Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability

Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized. Human CASPR2 autoantibodies, when injected into mice, were per...

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Detalles Bibliográficos
Autores principales: Dawes, John M., Weir, Greg A., Middleton, Steven J., Patel, Ryan, Chisholm, Kim I., Pettingill, Philippa, Peck, Liam J., Sheridan, Joseph, Shakir, Akila, Jacobson, Leslie, Gutierrez-Mecinas, Maria, Galino, Jorge, Walcher, Jan, Kühnemund, Johannes, Kuehn, Hannah, Sanna, Maria D., Lang, Bethan, Clark, Alex J., Themistocleous, Andreas C., Iwagaki, Noboru, West, Steven J., Werynska, Karolina, Carroll, Liam, Trendafilova, Teodora, Menassa, David A., Giannoccaro, Maria Pia, Coutinho, Ester, Cervellini, Ilaria, Tewari, Damini, Buckley, Camilla, Leite, M. Isabel, Wildner, Hendrik, Zeilhofer, Hanns Ulrich, Peles, Elior, Todd, Andrew J., McMahon, Stephen B., Dickenson, Anthony H., Lewin, Gary R., Vincent, Angela, Bennett, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011627/
https://www.ncbi.nlm.nih.gov/pubmed/29429934
http://dx.doi.org/10.1016/j.neuron.2018.01.033

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