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Vestibulovaginal Sclerosis Versus Lichen Sclerosus
To determine if vestibulovaginal sclerosis and lichen sclerosus (LS) are 2 distinct entities. Biopsies obtained from the vagina or vulvar vestibule that contained abnormal subepithelial collagen were reviewed. Cases were categorized either as LS or vestibulovaginal sclerosis based on presence or abs...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012045/ https://www.ncbi.nlm.nih.gov/pubmed/29194107 http://dx.doi.org/10.1097/PGP.0000000000000441 |
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author | Day, Tania Burston, Kate Dennerstein, Graeme Pagano, Ross Scurry, James |
author_facet | Day, Tania Burston, Kate Dennerstein, Graeme Pagano, Ross Scurry, James |
author_sort | Day, Tania |
collection | PubMed |
description | To determine if vestibulovaginal sclerosis and lichen sclerosus (LS) are 2 distinct entities. Biopsies obtained from the vagina or vulvar vestibule that contained abnormal subepithelial collagen were reviewed. Cases were categorized either as LS or vestibulovaginal sclerosis based on presence or absence of basal layer degeneration and lymphocytic infiltrate. Clinical data collected included examination findings, biopsy site and indication, previous vulvovaginal surgery, medications at time of biopsy, vulvar LS, treatment, and response. There were 15 cases with a mean age of 62 yr (range: 32–86 yr); 12 (80%) specimens were from vestibule and 3 from vagina. Nine cases were categorized as LS because of lymphocytic infiltrate in combination with basal layer degeneration, of these 8 had LS elsewhere on vulvar skin. Six cases were classified as vestibulovaginal sclerosis and had an absent or sparse lymphocytic infiltrate and essentially normal epithelium; none of these had vulvar LS. While vestibulovaginal sclerosis and lichen sclerosus are distinguishable clinically and histopathologically, further studies are needed to determine if vestibulovaginal sclerosis is a subset of LS or a different condition. |
format | Online Article Text |
id | pubmed-6012045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-60120452018-07-03 Vestibulovaginal Sclerosis Versus Lichen Sclerosus Day, Tania Burston, Kate Dennerstein, Graeme Pagano, Ross Scurry, James Int J Gynecol Pathol Pathology of the Lower Genital Tract: Original Articles To determine if vestibulovaginal sclerosis and lichen sclerosus (LS) are 2 distinct entities. Biopsies obtained from the vagina or vulvar vestibule that contained abnormal subepithelial collagen were reviewed. Cases were categorized either as LS or vestibulovaginal sclerosis based on presence or absence of basal layer degeneration and lymphocytic infiltrate. Clinical data collected included examination findings, biopsy site and indication, previous vulvovaginal surgery, medications at time of biopsy, vulvar LS, treatment, and response. There were 15 cases with a mean age of 62 yr (range: 32–86 yr); 12 (80%) specimens were from vestibule and 3 from vagina. Nine cases were categorized as LS because of lymphocytic infiltrate in combination with basal layer degeneration, of these 8 had LS elsewhere on vulvar skin. Six cases were classified as vestibulovaginal sclerosis and had an absent or sparse lymphocytic infiltrate and essentially normal epithelium; none of these had vulvar LS. While vestibulovaginal sclerosis and lichen sclerosus are distinguishable clinically and histopathologically, further studies are needed to determine if vestibulovaginal sclerosis is a subset of LS or a different condition. Lippincott Williams & Wilkins 2018-07 2017-12-01 /pmc/articles/PMC6012045/ /pubmed/29194107 http://dx.doi.org/10.1097/PGP.0000000000000441 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Society of Gynecological Pathologists This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Pathology of the Lower Genital Tract: Original Articles Day, Tania Burston, Kate Dennerstein, Graeme Pagano, Ross Scurry, James Vestibulovaginal Sclerosis Versus Lichen Sclerosus |
title | Vestibulovaginal Sclerosis Versus Lichen Sclerosus |
title_full | Vestibulovaginal Sclerosis Versus Lichen Sclerosus |
title_fullStr | Vestibulovaginal Sclerosis Versus Lichen Sclerosus |
title_full_unstemmed | Vestibulovaginal Sclerosis Versus Lichen Sclerosus |
title_short | Vestibulovaginal Sclerosis Versus Lichen Sclerosus |
title_sort | vestibulovaginal sclerosis versus lichen sclerosus |
topic | Pathology of the Lower Genital Tract: Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012045/ https://www.ncbi.nlm.nih.gov/pubmed/29194107 http://dx.doi.org/10.1097/PGP.0000000000000441 |
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