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Vestibulovaginal Sclerosis Versus Lichen Sclerosus

To determine if vestibulovaginal sclerosis and lichen sclerosus (LS) are 2 distinct entities. Biopsies obtained from the vagina or vulvar vestibule that contained abnormal subepithelial collagen were reviewed. Cases were categorized either as LS or vestibulovaginal sclerosis based on presence or abs...

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Autores principales: Day, Tania, Burston, Kate, Dennerstein, Graeme, Pagano, Ross, Scurry, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012045/
https://www.ncbi.nlm.nih.gov/pubmed/29194107
http://dx.doi.org/10.1097/PGP.0000000000000441
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author Day, Tania
Burston, Kate
Dennerstein, Graeme
Pagano, Ross
Scurry, James
author_facet Day, Tania
Burston, Kate
Dennerstein, Graeme
Pagano, Ross
Scurry, James
author_sort Day, Tania
collection PubMed
description To determine if vestibulovaginal sclerosis and lichen sclerosus (LS) are 2 distinct entities. Biopsies obtained from the vagina or vulvar vestibule that contained abnormal subepithelial collagen were reviewed. Cases were categorized either as LS or vestibulovaginal sclerosis based on presence or absence of basal layer degeneration and lymphocytic infiltrate. Clinical data collected included examination findings, biopsy site and indication, previous vulvovaginal surgery, medications at time of biopsy, vulvar LS, treatment, and response. There were 15 cases with a mean age of 62 yr (range: 32–86 yr); 12 (80%) specimens were from vestibule and 3 from vagina. Nine cases were categorized as LS because of lymphocytic infiltrate in combination with basal layer degeneration, of these 8 had LS elsewhere on vulvar skin. Six cases were classified as vestibulovaginal sclerosis and had an absent or sparse lymphocytic infiltrate and essentially normal epithelium; none of these had vulvar LS. While vestibulovaginal sclerosis and lichen sclerosus are distinguishable clinically and histopathologically, further studies are needed to determine if vestibulovaginal sclerosis is a subset of LS or a different condition.
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spelling pubmed-60120452018-07-03 Vestibulovaginal Sclerosis Versus Lichen Sclerosus Day, Tania Burston, Kate Dennerstein, Graeme Pagano, Ross Scurry, James Int J Gynecol Pathol Pathology of the Lower Genital Tract: Original Articles To determine if vestibulovaginal sclerosis and lichen sclerosus (LS) are 2 distinct entities. Biopsies obtained from the vagina or vulvar vestibule that contained abnormal subepithelial collagen were reviewed. Cases were categorized either as LS or vestibulovaginal sclerosis based on presence or absence of basal layer degeneration and lymphocytic infiltrate. Clinical data collected included examination findings, biopsy site and indication, previous vulvovaginal surgery, medications at time of biopsy, vulvar LS, treatment, and response. There were 15 cases with a mean age of 62 yr (range: 32–86 yr); 12 (80%) specimens were from vestibule and 3 from vagina. Nine cases were categorized as LS because of lymphocytic infiltrate in combination with basal layer degeneration, of these 8 had LS elsewhere on vulvar skin. Six cases were classified as vestibulovaginal sclerosis and had an absent or sparse lymphocytic infiltrate and essentially normal epithelium; none of these had vulvar LS. While vestibulovaginal sclerosis and lichen sclerosus are distinguishable clinically and histopathologically, further studies are needed to determine if vestibulovaginal sclerosis is a subset of LS or a different condition. Lippincott Williams & Wilkins 2018-07 2017-12-01 /pmc/articles/PMC6012045/ /pubmed/29194107 http://dx.doi.org/10.1097/PGP.0000000000000441 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Society of Gynecological Pathologists This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Pathology of the Lower Genital Tract: Original Articles
Day, Tania
Burston, Kate
Dennerstein, Graeme
Pagano, Ross
Scurry, James
Vestibulovaginal Sclerosis Versus Lichen Sclerosus
title Vestibulovaginal Sclerosis Versus Lichen Sclerosus
title_full Vestibulovaginal Sclerosis Versus Lichen Sclerosus
title_fullStr Vestibulovaginal Sclerosis Versus Lichen Sclerosus
title_full_unstemmed Vestibulovaginal Sclerosis Versus Lichen Sclerosus
title_short Vestibulovaginal Sclerosis Versus Lichen Sclerosus
title_sort vestibulovaginal sclerosis versus lichen sclerosus
topic Pathology of the Lower Genital Tract: Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012045/
https://www.ncbi.nlm.nih.gov/pubmed/29194107
http://dx.doi.org/10.1097/PGP.0000000000000441
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